Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Yaxing ZhangTinghuai Wang

Abstract

Hydrogen (H2) is colorless, odorless, and the lightest of gas molecules. Studies in the past ten years have indicated that H2 is extremely important in regulating the homeostasis of the cardiovascular system and metabolic activity. Delivery of H2 by various strategies improves cardiometabolic diseases, including atherosclerosis, vascular injury, ischemic or hypertrophic ventricular remodeling, intermittent hypoxia- or heart transplantation-induced heart injury, obesity and diabetes in animal models or in clinical trials. The purpose of this review is to summarize the physical and chemical properties of H2, and then, the functions of H2 with an emphasis on the therapeutic potential and molecular mechanisms involved in the diseases above. We hope this review will provide the future outlook of H2-based therapies for cardiometabolic disease.

Citations

Jun 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tyler W LeBaronJan Slezak
Jul 4, 2019·Advanced Healthcare Materials·Gaoxin ZhouQianjun He
Jan 15, 2020·Open Medicine·Fu-Han GongYong-Sheng Yang
Jul 1, 2020·Frontiers in Pharmacology·Yaxing ZhangHongzhi Yang
Jul 3, 2020·Frontiers in Cell and Developmental Biology·Yaxing ZhangHongzhi Yang
Jan 30, 2021·Oxidative Medicine and Cellular Longevity·Yaxing ZhangLequan Zhou
Mar 7, 2021·Cancers·Luc RochetteCatherine Vergely
Aug 9, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiongge HuAnwen Shao

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