Hydrogen Water Drinking Exerts Antifatigue Effects in Chronic Forced Swimming Mice via Antioxidative and Anti-Inflammatory Activities

BioMed Research International
Jesmin AraKyu-Jae Lee

Abstract

This study was performed to evaluate antifatigue effect of hydrogen water (HW) drinking in chronic forced exercise mice model. Twelve-week-old C57BL6 female mice were divided into nonstressed normal control (NC) group and stressed group: (purified water/PW-treated group and HW-treated group). Stressed groups were supplied with PW and HW, respectively, ad libitum and forced to swim for the stress induction every day for 4 consecutive weeks. Gross antifatigue effects of HW were assessed by swimming endurance capacity (once weekly for 4 wk), metabolic activities, and immune-redox activities. Metabolic activities such as blood glucose, lactate, glycogen, blood urea nitrogen (BUN), and lactate dehydrogenase (LDH) as well as immune-redox activities such as reactive oxygen species (ROS), nitric oxide (NO), glutathione peroxidase (GPx), catalase, and the related cytokines were evaluated to elucidate underlying mechanism. Blood glucose and lactate were measured at 0 wk (before swimming) and 4 wk (after swimming). HW group showed a higher swimming endurance capacity (p < 0.001) than NC and PW groups. Positive metabolic effects in HW group were revealed by the significant reduction of blood glucose, lactate, and BUN in serum after 4 wk (p...Continue Reading

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Citations

Apr 11, 2019·Canadian Journal of Physiology and Pharmacology·Tyler W LeBaronJan Slezak
Feb 12, 2020·International Journal of Sports Physiology and Performance·Michal BotekBarbora Sládečková
Mar 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yanni ZhangYitao Jia
Sep 12, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisMichael Berk
Jan 18, 2021·Journal of Thermal Biology·Shinya KatoNobuhiko Miwa
Sep 24, 2020·Current Pharmaceutical Design·Sergej M Ostojic
Nov 14, 2020·Current Pharmaceutical Design·Jonatas E Nogueira, Luiz G S Branco

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Methods Mentioned

BETA
protein assay

Software Mentioned

GraphPad
GraphPad Prism

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