Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague-Dawley rats

Pharmaceutical Biology
Thanawat PattananandechaChaiyavat Chaiyasut

Abstract

Context Inulin, a non-digestible carbohydrate isolated from Helianthus tuberosus L. (Asteraceae), has been shown to alter the gut beneficial bacteria including Lactobacillus spp. and Bifidobacteria. Inulin also influences the activities of intestinal microbiota that could prevent the colon cancer development. Objective This study determines the effect of hydrolysed inulin with different degrees of polymerisation on alteration of intestinal microbiota and their activities on azoxymethane (AOM)-induced preneoplastic aberrant crypt foci (ACF) in rats. Materials and methods Seventy-two male Sprague-Dawley rats were randomly divided into six groups (three control and three AOM-treated groups) and the animal were fed with either a normal diet or diet containing 10% of long-chain inulin (InuL) or short-chain inulin (InuS), respectively, for 17 weeks. Colon cancer was induced in rats by injecting AOM subcutaneously at the 8th and 9th week of the study period. At the end of the experiment, cecal contents of rats were examined for selected microbiota, organic acids, putrefactive compounds and microbial enzymes. ACF formation was microscopically examined. Results The inulin diets significantly increased the weight and decreased the pH of ...Continue Reading

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Citations

Apr 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min XieMing-Yong Xie
Sep 29, 2017·Frontiers in Microbiology·Chiara FerrarioFrancesca Turroni
Aug 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Tianqing SangHongguang Zhou
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Feb 24, 2018·Genomics, Proteomics & Bioinformatics·Changting MengQiang Tian
Nov 14, 2020·Carbohydrate Polymers·Shuli ManFuping Lu

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