PMID: 15376524Sep 21, 2004Paper

Hydrolysis and photolysis of paroxetine, a selective serotonin reuptake inhibitor, in aqueous solutions

Environmental Toxicology and Chemistry
Jeong-Wook Kwon, Kevin L Armbrust

Abstract

The hydrolysis and photolysis of paroxetine HCI, a selective serotonin reuptake inhibitor, in aqueous buffer solutions (pH 5, 7, and 9), in synthetic humic water, and in lake water were investigated at 25 degrees C in the dark and in a growth chamber outfitted with fluorescent lamps simulating the ultraviolet (UV) output of sunlight. Paroxetine was degraded completely within 4 d by simulated sunlight in all aqueous media. Photolysis of paroxetine HCI was accelerated by increasing pH. The t1/2 values at pH 5, 7, and 9 were 15.79, 13.11, and 11.35 h, respectively. The half-lives of paroxetine in synthetic humic water and two lake waters were slightly longer than in pH 7 buffer. Two photoproducts were detected and their structures were identified by liquid chromatography-mass spectrometry in positive mode. Photoproduct I was found to be photolytically unstable, being gradually degraded after 12 to 18 h of irradiation. However, photoproduct II was photolytically very stable throughout the experiment period, indicating that it was persistent to further photodegradation. In the dark, paroxetine in all aqueous solutions was found to be stable over a 30-d period. In conclusion, paroxetine is a relatively photolabile drug that has a pos...Continue Reading

Citations

Apr 6, 2006·Chemical & Pharmaceutical Bulletin·Nawal AlarfajMaha Sultan
Apr 5, 2008·Bulletin of Environmental Contamination and Toxicology·Jeong-Wook Kwon, Kevin L Armbrust
Jul 22, 2014·Environmental Toxicology and Chemistry·Ralph N MeadRobert J Kieber
Feb 8, 2014·Aquatic Toxicology·Bryan W Brooks
Sep 4, 2012·The Science of the Total Environment·Liliana J G SilvaAngelina Pena
Feb 24, 2015·Ecotoxicology and Environmental Safety·Milena WawryniukGrzegorz Nałęcz-Jawecki
Oct 4, 2016·Environmental Science and Pollution Research International·Jakub Trawiński, Robert Skibiński
Mar 31, 2005·Journal of Pharmaceutical and Biomedical Analysis·Jeong-Wook Kwon, Kevin L Armbrust
Sep 14, 2018·Environmental Science. Processes & Impacts·Reid P MilsteadDavid R Griffith
Mar 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Grzegorz Nałęcz-JaweckiAgata Drobniewska
Dec 23, 2017·Environmental Science and Pollution Research International·Milena WawryniukGrzegorz Nałęcz-Jawecki
Apr 20, 2011·Organic & Biomolecular Chemistry·Davor ŠakićValerije Vrček
May 29, 2007·Chemical Reviews·Sushil K Khetan, Terrence J Collins
Aug 11, 2020·Journal of Environmental Management·Bartosz KózkaJoanna Giebułtowicz

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