PMID: 7085886Jul 1, 1982Paper

Hydrolysis of milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts

The Journal of Clinical Investigation
B Borgström, Charlotte Erlanson-Albertsson

Abstract

Human milk fat globules require colipase to be hydrolyzed by pancreatic lipase in the presence of bile salts. This is contrary to a recent report in this Journal (J. Clin. Invest. 67: 1748-1752.) according to which inhibition of lipase by bile salt could be overcome by the addition of colipase or phospholipase A2. This latter finding is shown to be due to contamination of commercially available pancreatic phospholipase A2 by colipase.

References

Dec 15, 1979·FEBS Letters·B BorgströmCharlotte Erlanson-Albertsson
Jan 1, 1976·Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry·J Donnér
Dec 3, 1973·European Journal of Biochemistry·W NieuwenhuizenG H de Haas
Jun 1, 1981·The Journal of Clinical Investigation·L BläckbergT Olivecrona

Citations

Jan 6, 2007·Digestive Diseases and Sciences·David C Whitcomb, Mark E Lowe
Jun 24, 2011·Chemical Reviews·Jonathan Z Long, Benjamin F Cravatt
Jan 1, 1997·Annual Review of Nutrition·Mark E Lowe
Jan 1, 2010·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Sonia A TucciJason Cg Halford
Apr 21, 1999·Biochimica Et Biophysica Acta·T KäämbreP Sikk
Nov 25, 2004·Best Practice & Research. Clinical Gastroenterology·L Van GaalH J Verkade
Dec 8, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Selena Di Maio, Rebecca L Carrier
Jul 14, 1989·Biochemical and Biophysical Research Communications·I M RobertsJ Cornette
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antonio Pérez-GálvezJavier Fontecha

Related Concepts

Bile Salts
Colipases
Hydrolysis
Exolipase
Milk, Human
Pancreas
Phospholipases A
Triglycerides
Phospholipases A2

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