PMID: 7085886Jul 1, 1982Paper

Hydrolysis of milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts

The Journal of Clinical Investigation
B Borgström, Charlotte Erlanson-Albertsson


Human milk fat globules require colipase to be hydrolyzed by pancreatic lipase in the presence of bile salts. This is contrary to a recent report in this Journal (J. Clin. Invest. 67: 1748-1752.) according to which inhibition of lipase by bile salt could be overcome by the addition of colipase or phospholipase A2. This latter finding is shown to be due to contamination of commercially available pancreatic phospholipase A2 by colipase.


Dec 15, 1979·FEBS Letters·B BorgströmCharlotte Erlanson-Albertsson
Jan 1, 1976·Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry·J Donnér
Dec 3, 1973·European Journal of Biochemistry·W NieuwenhuizenG H de Haas
Jun 1, 1981·The Journal of Clinical Investigation·L BläckbergT Olivecrona


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Jun 24, 2011·Chemical Reviews·Jonathan Z Long, Benjamin F Cravatt
Jan 1, 1997·Annual Review of Nutrition·Mark E Lowe
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Apr 21, 1999·Biochimica Et Biophysica Acta·T KäämbreP Sikk
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Related Concepts

Bile Salts
Milk, Human
Phospholipases A
Phospholipases A2

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