Hydrolysis of sulphonamides in aqueous solutions

Journal of Hazardous Materials
Anna Białk-BielińskaJolanta Kumirska

Abstract

Hydrolysis is one of the most common reactions controlling abiotic degradation and is one of the main paths by which substances are degraded in the environment. Nevertheless, the available information on this process for many compounds, including sulphonamides (a group of antibiotic drugs widely used in veterinary medicine), is very limited. This is the first study investigating the hydrolytic stabilities of 12 sulphonamides, which were determined according to OECD guideline 111 (1st category reliability data on the basis of regulatory demands on data quality for the environmental risk assessment of pharmaceuticals). Hydrolysis behaviour was examined at pH values normally found in the environment. This was prefaced by a discussion of the acid-base properties of sulphonamides. All the sulphonamides tested were hydrolytically stable at pH 9.0, nine (apart from sulphadiazine, sulphachloropyridazine and sulphamethoxypyridazine) were stable in this respect at pH 7.0 and two (sulphadiazine and sulphaguanidine) at pH 4.0 (hydrolysis rate≤10%; t(0.5 (25°C))>1 year). The degradation products were identified, indicating two independent mechanisms of this process. Our results show that under typical environmental conditions (pH and temper...Continue Reading

References

Oct 17, 2002·Journal of Agricultural and Food Chemistry·Ajit K Sarmah, Jean Sabadie
Jun 30, 2005·Environmental Science & Technology·Anke GöbelWalter Giger
Feb 13, 2008·Journal of Environmental Quality·Keith A LoftinRao Surampalli
Sep 26, 2008·Journal of Environmental Quality·Melinda S Dalton, Elizabeth A Frick
Jan 9, 2009·Applied Microbiology and Biotechnology·Xu-Xiang ZhangHerbert H P Fang
Feb 3, 2009·Chemosphere·Klaus Kümmerer
Jul 18, 2009·Regulatory Toxicology and Pharmacology : RTP·A KüsterB Rechenberg
May 29, 2010·Applied Microbiology and Biotechnology·Chang Ding, Jianzhong He
Jul 14, 2010·Water Research·N Le-MinhR M Stuetz
Nov 11, 2010·Analytical and Bioanalytical Chemistry·Despo Fatta-KassinosAnastasia Nikolaou
Apr 9, 2011·Environmental Science & Technology·Beate I Escher, Kathrin Fenner
Jun 18, 2011·Journal of Environmental Management·Vera Homem, Lúcia Santos
Jul 15, 2011·Chemosphere·Anna Białk-BielińskaMarianne Matzke

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Citations

May 28, 2014·Environmental Science and Pollution Research International·Marie-Virginie SalviaEmmanuelle Vulliet
Mar 8, 2016·Journal of Environmental Management·Xinbo ZhangWei Wu
May 3, 2016·Journal of Hazardous Materials·Zane N NorvillBenoit Guieysse
Jul 3, 2013·Journal of Hazardous Materials·Joanna MaszkowskaUte Kalbe
Jul 7, 2014·Chemosphere·Joanna MaszkowskaAnna Białk-Bielińska
Sep 13, 2014·Journal of Hazardous Materials·Aleksandra FabiańskaEwa Maria Siedlecka
Jul 28, 2016·Environmental Pollution·Martin KočárekRoman Grabic
Nov 15, 2016·Critical Reviews in Analytical Chemistry·Hanna MęczykowskaMagda Caban
Mar 5, 2017·Environmental Science and Pollution Research International·Martina BiošićSandra Babić
Apr 13, 2017·Analytical and Bioanalytical Chemistry·Hanna MęczykowskaMagda Caban
Jul 22, 2017·SAR and QSAR in Environmental Research·N H DimitrovaC Hamaguchi
Sep 11, 2019·Water Environment Research : a Research Publication of the Water Environment Federation·Elnaz Jafari OzumcheloueiMin Yang
Dec 13, 2019·Environmental Microbiology·Felipe C CabelloAlexandra Tomova
Dec 6, 2019·Tropical Medicine & International Health : TM & IH·Brunna Soares Rodrigues CostaLourena Mafra Veríssimo
Apr 22, 2015·Environmental Science and Pollution Research International·Joanna MaszkowskaPiotr Stepnowski
Apr 19, 2020·Bulletin of Environmental Contamination and Toxicology·Kyongjin PangJiye Hu
Aug 20, 2019·The Science of the Total Environment·Zuzana BílkováKarel Hrich
Jun 10, 2021·Environmental Science and Pollution Research International·Michał TońskiAnna Białk-Bielińska

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