Hydrolytic and oxidative degradation of electrospun supramolecular biomaterials: In vitro degradation pathways

Acta Biomaterialia
M C P BrugmansA Driessen-Mol

Abstract

The emerging field of in situ tissue engineering (TE) of load bearing tissues places high demands on the implanted scaffolds, as these scaffolds should provide mechanical stability immediately upon implantation. The new class of synthetic supramolecular biomaterial polymers, which contain non-covalent interactions between the polymer chains, thereby forming complex 3D structures by self assembly. Here, we have aimed to map the degradation characteristics of promising (supramolecular) materials, by using a combination of in vitro tests. The selected biomaterials were all polycaprolactones (PCLs), either conventional and unmodified PCL, or PCL with supramolecular hydrogen bonding moieties (either 2-ureido-[1H]-pyrimidin-4-one or bis-urea units) incorporated into the backbone. As these materials are elastomeric, they are suitable candidates for cardiovascular TE applications. Electrospun scaffold strips of these materials were incubated with solutions containing enzymes that catalyze hydrolysis, or solutions containing oxidative species. At several time points, chemical, morphological, and mechanical properties were investigated. It was demonstrated that conventional and supramolecular PCL-based polymers respond differently to enz...Continue Reading

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Apr 11, 2018·Journal of Biomedical Materials Research. Part a·Maksym PogorielovJakub Erben
Jan 6, 2018·Npj Regenerative Medicine·Tamar B WissingAnthal I P M Smits
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Dec 17, 2020·Journal of Clinical Medicine·Simon Raveau, Fabienne Jordana
May 27, 2021·Advanced Healthcare Materials·Hieu T BuiLakshmi Prasad Dasi
Jul 16, 2021·Journal of Polymer Science·Ronald C van GaalPatricia Y W Dankers

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