PMID: 15348037Sep 7, 2004Paper

Hydrolytic degradation of PCL/PEO copolymers in alkaline media

Journal of Materials Science. Materials in Medicine
S M LiS P McCarthy

Abstract

PCL/PEO copolymers with different compositions were obtained from ring opening polymerization of epsilon-caprolactone in the presence of ethylene oxide and characterized by various analytical techniques. Data collected from DSC and X-ray diffractometry suggested that the copolymer chains possess a blocky structure, leading to both PCL and PEO-type crystalline structures. Hydrolytic degradation of these copolymers was carried out in a pH=10.6 carbonate buffer solution at 37 degrees C. Comparison was made with a PCL homopolymer and a PCL/PEG blend which had the same gross composition as one of the copolymers. The results showed that the presence of PEO sequences considerably enhanced the hydrophilicity of the copolymers as compared with PCL homopolymer. Nevertheless, the degradability of PCL chains was not enhanced due to the phase separation between the two components. These materials should be of great interest for biomedical uses such as matrices for sustained drug delivery because of the presence of both hydrophilic and hydrophobic microdomains.

Citations

Sep 10, 2011·Tissue Engineering. Part a·Christiane L SalgadoPedro L Granja
Oct 26, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wen-Jen LinJi-Wang Chen
Sep 1, 2010·Craniomaxillofacial Trauma & Reconstruction·Samuel Y M HoMarcus T C Wong
Mar 28, 2020·Polymers·Anita Ioana VisanGabriel Socol
Dec 18, 2001·Journal of Biomedical Materials Research·Daniel CohnJulia Epstein
Dec 10, 2003·Journal of Biomaterials Science. Polymer Edition·Jong-Ho KimYou Han Bae
Oct 18, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Thomas J JoncherayRandolph S Duran

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