Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Hitomi OzakiShigeyuki Kitamura

Abstract

Salicylates are used as fragrance and flavor ingredients for foods, as UV absorbers and as medicines. Here, we examined the hydrolytic metabolism of phenyl and benzyl salicylates by various tissue microsomes and plasma of rats, and by human liver and small-intestinal microsomes. Both salicylates were readily hydrolyzed by tissue microsomes, predominantly in small intestine, followed by liver, although phenyl salicylate was much more rapidly hydrolyzed than benzyl salicylate. The liver and small-intestinal microsomal hydrolase activities were completely inhibited by bis(4-nitrophenyl)phosphate, and could be extracted with Triton X-100. Phenyl salicylate-hydrolyzing activity was co-eluted with carboxylesterase activity by anion exchange column chromatography of the Triton X-100 extracts of liver and small-intestinal microsomes. Expression of rat liver and small-intestinal isoforms of carboxylesterase, Ces1e and Ces2c (AB010632), in COS cells resulted in significant phenyl salicylate-hydrolyzing activities with the same specific activities as those of liver and small-intestinal microsomes, respectively. Human small-intestinal microsomes also exhibited higher hydrolyzing activity than liver microsomes towards these salicylates. Hum...Continue Reading

References

Nov 1, 1975·American Industrial Hygiene Association Journal·W A FishbeckR J Kociba
Jul 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·C J O'ConnorR G Wallace
Feb 1, 1973·Biochemical Pharmacology·R P Koshakji, A R Schulert
Jul 6, 1971·Annals of the New York Academy of Sciences·C Davison
Apr 1, 1971·Toxicology and Applied Pharmacology·T F CollinsH V Keeler
Jun 1, 1994·Acta Odontologica Scandinavica·H LygreN R Gjerdet
Mar 1, 1996·Toxicology Letters·D P DavisA L Kraus
Apr 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tetsuo SatohBert N La Du
Sep 17, 2002·European Journal of Biochemistry·Sonal P SanghaniWilliam F Bosron
Apr 14, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K MorohoshiM Morita
Jun 14, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T B AdamsUNKNOWN Expert Panel of the Flavor and Extract Manufacturers Association
May 17, 2006·Drug Metabolism and Pharmacokinetics·Satoshi YamaoriKazuhito Watanabe
Jul 14, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Teruko ImaiKan Chiba
Aug 22, 2006·Chemico-biological Interactions·Tetsuo Satoh, Masakiyo Hosokawa
Sep 12, 2006·Journal of Molecular Biology·Sompop BencharitMatthew R Redinbo
Jul 27, 2007·Biochemical Pharmacology·Christopher JewellFaith M Williams
Nov 23, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A LapczynskiA M Api
Nov 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A LapczynskiA M Api
Feb 29, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Masakiyo Hosokawa
Jan 1, 2007·Drug Metabolism Letters·Heather M HarvilleJeffery J Prusakiewicz
Oct 12, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Roger S HolmesLois J Maltais
Jun 8, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hitomi OzakiShigeyuki Kitamura
Dec 18, 2013·Mini Reviews in Medicinal Chemistry·Ping MaoGaimei She
Jan 30, 2014·Journal of the American Academy of Dermatology·Raman K Madan, Jacob Levitt

❮ Previous
Next ❯

Citations

Jun 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Justyna PopiółElżbieta Pękala
Aug 20, 2021·Toxicology Reports·Andreas NatschHeike Laue

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Chieri FujinoShigeyuki Kitamura
Bollettino della Società italiana di biologia sperimentale
L Congiu
© 2021 Meta ULC. All rights reserved