Hydrolytic metal with a hydrophobic periphery: titanium(IV) complexes of naphthalene-2,3-diolate and interactions with serum albumin

Inorganic Chemistry
Arthur D TinocoAnn M Valentine

Abstract

Serum albumin, the most abundant protein in human plasma (700 microM), binds diverse ligands at multiple sites. While studies have shown that serum albumin binds hard metals in chelate form, few have explored the trafficking of these metals by this protein. Recent work demonstrated that serum albumin may play a pivotal role in the transport and bioactivity of titanium(IV) complexes, including the anticancer drug candidate titanocene dichloride. The current work explores this interaction further by using a stable Ti(IV) complex that presents a hydrophobic surface to the protein. Ti(IV) chelation by 2,3-dihydroxynaphthalene (H2L1) and 2,3-dihydroxynaphthalene-6-sulfonate (H2L2) affords water soluble complexes that protect Ti(IV) from hydrolysis at pH 7.4 and bind to bovine serum albumin (BSA). The solution and solid Ti(IV) coordination chemistry were explored by aqueous spectropotentiometric titrations and X-ray crystallography, respectively, and with complementary electrochemistry, mass spectrometry, and IR and NMR spectroscopies. Four Ti(IV) species of L2, TiLH0, TiL2H0, TiL3H0, and TiL3H(-1), adequately represent the pH-dependent speciation. The isolation of Ti(C10H6O2)2 x 1.75 H2O at pH approximately 3 and K2[Ti(C10H6O2)3] x ...Continue Reading

References

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Apr 6, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yi Zhang, Dean E Wilcox
Aug 11, 2005·Journal of the American Chemical Society·Arthur D Tinoco, Ann M Valentine
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Feb 24, 2007·Journal of the American Chemical Society·Arthur D TinocoAnn M Valentine
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Jan 30, 2008·Journal of the American Chemical Society·Arthur D TinocoAnn M Valentine
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Arthur D TinocoAnn M Valentine

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Citations

Nov 15, 2011·Chemical Reviews·Katherine M Buettner, Ann M Valentine
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Arthur D TinocoAnn M Valentine
Aug 13, 2011·Acta Crystallographica. Section E, Structure Reports Online·Yan-Hua GuoFan Yu
Jul 25, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhanfen ChenChanglin Liu
Apr 25, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Maria PavlakiAlexios J Aletras
Sep 10, 2014·Environmental Toxicology and Pharmacology·Yan-Qing WangJian Cao
Jul 26, 2011·Biochimica Et Biophysica Acta·John B Vincent, Sharifa Love
Feb 7, 2017·Metallomics : Integrated Biometal Science·Sergio A Loza-RosasArthur D Tinoco
Jun 4, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Chew-Hee NgWeng Kee Leong
Mar 4, 2014·Biotechnology, Biotechnological Equipment·Qingquan GuoJinhua Zeng
Oct 18, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhanfen ChenJian Zhang
Oct 3, 2018·Coordination Chemistry Reviews·Manoj SaxenaArthur D Tinoco
Apr 11, 2018·Journal of Inorganic Biochemistry·Rahel P Eberle, Stefan Schürch
May 30, 2021·Journal of Inorganic Biochemistry·Gilad NahariEdit Y Tshuva
Dec 24, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Hiromasa NishikioriHiroshi Satozono

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