Hydrolytically degradable hyperbranched PEG-polyester adhesive with low swelling and robust mechanical properties

Advanced Healthcare Materials
Hong ZhangWenxin Wang

Abstract

Photocrosslinkable and water soluble hyperbranched PEG-polyester polymers (HPEGDA) have been developed as robust degradable adhesives. The HPEGDA polymers have been synthesized from controlled homopolymerization of poly(ethylene glycol) diacrylate (PEGDA700 ) via in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). By introducing a high initiator-to-monomer ratio, the obtained HPEGDA polymer is composed of extremely short carbon-carbon backbones interconnected together by the long PEG chains as well as pendent photocrosslinkable acrylate moieties. Due to the extremely short C-C backbone, the long PEG chains can therefore be seen as the main chain, thus, HPEGDA polymers behave more like polyester which is a category of polymers that contain the ester functional group in their main chain. Photo-cured HPEGDA can be readily adhered to tissue forming a patch with robust mechanical and adhesive strengths. The degradation profile by hydrolysis of polyester blocks as well as a significantly low swelling ratio of HPEGDA gels in an aqueous environment allow them to have great potential for sealing and repair of internal tissue. Furthermore, HPEGDA gels appear to have minor significant cytotoxicity in vitro. These...Continue Reading

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Citations

Dec 15, 2016·ACS Applied Materials & Interfaces·Tristan HarperHoyong Chung
Sep 18, 2020·Advanced Healthcare Materials·Jiacheng ZhaoBenjamin J Wiley
Apr 12, 2016·Macromolecular Bioscience·Gao FengTerry W J Steele
Dec 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dedai LuZiqiang Lei
Jul 10, 2019·Advanced Materials·Haitao LiuJianhua Qin
Feb 25, 2020·Journal of Applied Polymer Science·Zhongtian ZhangBruce P Lee
Jan 12, 2021·Nano Today·Ayça Bal-OzturkShabir Hassan
Jan 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rui-Zhi TangXi-Qiu Liu
Jun 5, 2021·ACS Applied Materials & Interfaces·Katie M HerbertStuart J Rowan
Jun 25, 2021·ACS Biomaterials Science & Engineering·Yifan ZhangXiaoya Liu
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Yiwei ZhanChunying Chen
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nigel C S TanTerry W J Steele
Jul 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yifan ZhangXiaoya Liu
Sep 2, 2017·Biomacromolecules·Vrushali Bhagat, Matthew L Becker
Aug 29, 2019·ACS Omega·Xiacong ZhangAfang Zhang
Nov 21, 2020·Biomacromolecules·Yifan ZhangXiaoya Liu

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