Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators

Chemical Communications : Chem Comm
Yonggang XiangEric Meggers

Abstract

We here introduce octahedral silicon serving as a structural center for the design of hydrolytically stable bioactive complexes as demonstrated with the generation of silicon-based high affinity DNA binders. This proof-of-principle study suggests that octahedral silicon complexes are falsely neglected, promising structural templates for widespread applications in chemical biology and medicinal chemistry.

References

Aug 15, 1986·Science·J K Barton
Feb 3, 2000·Nature Structural Biology·C L KielkopfD C Rees
Mar 29, 2001·Inorganic Chemistry·B K KimP Boudjouk
Oct 24, 2001·Inorganic Chemistry·Rajesh B. NairCatherine J. Murphy
Dec 2, 2006·Nature Materials·Takehiko Yagi
Dec 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Valérie C PierreJacqueline K Barton
Feb 1, 2007·Chemical Society Reviews·Michael J Hannon
Nov 9, 2007·Chemical Communications : Chem Comm·Brian M ZeglisJacqueline K Barton
Feb 20, 2009·Chemical Communications : Chem Comm·Eric Meggers
Nov 19, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Catherine L DaviesAnne-K Duhme-Klair
Dec 19, 2009·Current Opinion in Chemical Biology·Chi-Ming Che, Fung-Ming Siu
Sep 17, 2010·Angewandte Chemie·Peter PortiusKlaus-Dieter Wehrstedt
Mar 31, 2011·Accounts of Chemical Research·Hong-Ke Liu, Peter J Sadler
Sep 1, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Konstantin JunoldReinhold Tacke
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·James P HallChristine J Cardin

❮ Previous
Next ❯

Citations

Apr 1, 2017·Future Medicinal Chemistry·Shinya Fujii, Yuichi Hashimoto
Apr 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chen FuGuojian Liao
Oct 19, 2017·Journal of Medicinal Chemistry·Remya Ramesh, D Srinivasa Reddy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dalton Transactions : an International Journal of Inorganic Chemistry
Oindrila Das, Tapan Kanti Paine
The ... Midwest Symposium on Circuits and Systems Conference Proceedings : MWSCAS
Christy M BogardEric C Rouchka
Chemistry & Biodiversity
Reinhold Tacke, Stefan Metz
© 2021 Meta ULC. All rights reserved