Hydrolyzed casein decreases postprandial glucose concentrations in T2DM patients irrespective of leucine content

Journal of Dietary Supplements
Bart F GeertsJacobus Burggraaf

Abstract

Lifestyle modifications, including diet, are important in the prevention and management of type 2 diabetes mellitus (T2DM). However, limited information is available on the effects of single doses of meal replacements, particularly with regard to their effect on postprandial glucose. Therefore, a study was performed comparing the effects of a single meal replacement in T2DM patients on postprandial serum glucose, insulin, and glucagon. This randomized, double-blind, partial cross-over study was performed in 36 T2DM patients who continued their oral anti-diabetic medication. Each patient received three out of four treatments separated by 7 days. The treatments were a proprietary casein hydrolysate (insuVida™) alone or with additional leucine, unhydrolyzed casein, or placebo. Blood sampling was done for 4 hr. Treatments were compared using repeated measures ANOVA. Results are given as an estimate of the difference (%) for the 4-hr epoch. Glucose concentrations were lowered by -4.7% by insuVida and insuVida plus added leucine compared to placebo (95% CI: -1.6 to -7.7%), while the effect of unhydrolyzed casein was -1.7% (-4.8 to 1.5%). Addition of leucine to insuVida induced the greatest increase in insulin (i.e., 51.8%; 41.1 to 63...Continue Reading

References

Nov 1, 1978·Clinical Endocrinology·J L DayW Midgley
Sep 1, 1985·Endocrinology·D G PipeleersM Van de Winkel
Nov 1, 1988·Metabolism: Clinical and Experimental·M C GannonS A Westphal
Oct 1, 1968·Metabolism: Clinical and Experimental·J A Pallotta, P J Kennedy
Sep 1, 1980·The American Journal of Clinical Nutrition·M AhmedR F Lamusga
Jun 29, 2000·The American Journal of Clinical Nutrition·L J van LoonA J Wagenmakers
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Jun 26, 2002·The American Journal of Clinical Nutrition·Michelle D AlthuisJanet T Wittes
Dec 12, 2002·Diabetes·Peter ProksFrances Ashcroft
Apr 1, 1956·The Journal of Clinical Investigation·W A COCHRANEL I WOOLF
Oct 3, 2003·The American Journal of Clinical Nutrition·Mary C GannonHeidi Hoover
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Mary F CarrollDavid S Schade
Nov 17, 2004·Clinical Science·Philip NewsholmePierre Maechler
Jun 1, 2005·Archives of Medical Research·Fernando Guerrero-Romero, Martha Rodríguez-Morán
Aug 25, 2007·European Journal of Clinical Nutrition·R J F MandersL J C van Loon
May 1, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·C RoumenE E Blaak

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Citations

Aug 23, 2012·Peptides·Alice B Nongonierma, Richard J Fitzgerald
Jun 2, 2015·Food & Function·Alice B Nongonierma, Richard J FitzGerald
May 7, 2016·The Proceedings of the Nutrition Society·Ágnes A FeketeJulie A Lovegrove
May 21, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Dalila Azzout-MarnicheDaniel Tomé
Dec 14, 2018·Journal of Nutritional Science·Hanna Fjeldheim DaleGülen Arslan Lied
May 22, 2019·Diabetes/metabolism Research and Reviews·Khemayanto HidayatBi-Min Shi
Jul 1, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Daniela FangmannMatthias Laudes
Apr 12, 2018·Journal of Agricultural and Food Chemistry·Elaine DrummondLorraine Brennan
Mar 19, 2022·Journal of Agricultural and Food Chemistry·Pauline DuffulerJianping Wu

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