Hydropathy analysis to correlate structure and function of proteins

Biochemical and Biophysical Research Communications
Lakshminarasimhan Damodharan, Vasantha Pattabhi

Abstract

In post-genomic era, a plethora of protein structures have been solved but the functions of some of them are unknown. In this context, the role of hydropathy index of amino acids in predicting the function of a structurally known and functionally unknown protein was explored. Initially serine protease class was taken for analysis. Various methodologies like calculation of average hydropathy index for a five-residue window of a given sequence, hydropathy cluster analyses, etc., were done. Among these, the distribution of hydropathy clusters seems to suggest that the location of these clusters is conserved for a given class of proteins. Hence, this methodology was extended to different classes of proteins and to a protein with unknown function.

References

Dec 10, 1998·Nucleic Acids Research·H W MewesD Frishman
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Dec 10, 1998·Nucleic Acids Research·A Bairoch

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Citations

Jan 14, 2010·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·J Dennis PollackDennis K Pearl
Jun 3, 2009·Genome Biology·Michelle Simon, John M Hancock
Nov 10, 2007·Journal of the American Chemical Society·Jose J PastorErnest Giralt

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