Hydrophilic-hydrophobic microdomain surfaces having an ability to suppress platelet aggregation and their in vitro antithrombogenicity

Journal of Biomedical Materials Research
T OkanoI Shinohara

Abstract

Block copolymers were synthesized by a coupling reaction of hydrophilic chains of poly(2-hydroxyethyl methacrylate) (PHEMA) with hydrophobic chains of polystyrene (PSt), or poly(dimethyl siloxane) (PDMS). Microstructures of films of the block copolymers exhibited a hydrophilic-hydrophobic microphase separated structure. For evaluation of in vivo antithrombogenicity, small diameter tubes (1.5 mm I.D. and 20 cm length) coated by the copolymers on their internal surfaces were implanted in rabbits as arteriovenous shunts. Occlusion times of the tubes, measured by formation of thrombus, were three days for PHEMA, two days for PSt, and three days for PDMS. The block copolymers showed excellent antithrombogenic properties: occlusion times were 20 days for HEMA-St block copolymer and 12 days for HEMA-DMS block copolymers. In vitro examination of polymer-platelet interaction in terms of platelet adhesion and aggregation, which are important initial processes of blood coagulation, demonstrated suppressed adhesion and aggregation on microdomain surfaces constructed of hydrophilic and hydrophobic block copolymers. From both in vivo and in vitro examination, it was concluded that HEMA-St and HEMA-DMS block copolymers showed promising antith...Continue Reading

References


❮ Previous
Next ❯

Citations

Sep 1, 1990·Journal of Biomedical Materials Research·C NojiriS W Kim
Mar 1, 1993·Journal of Biomedical Materials Research·K FujimotoY Ikada
Feb 27, 2004·Journal of Colloid and Interface Science·L HermitteC Martelet
May 11, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Lei Shen, X-Y Zhu
Nov 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francis VerbekeRaymond Vanholder
Apr 18, 2012·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Scott R SchrickerBharat Bhushan
Jan 1, 1995·Artificial Organs·C NojiriT Okano
Aug 6, 2002·Journal of Biomaterials Science. Polymer Edition·F D Rubens
Jan 31, 2003·Journal of Biomaterials Science. Polymer Edition·A A DeschampsJ Feijen
Jan 18, 2006·Journal of Biomaterials Science. Polymer Edition·Aashiish AgnihotriChristopher A Siedlecki
Jan 1, 1990·Journal of Biomaterials Science. Polymer Edition·A Z PiaoS W Kim
Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·T AokiT Okano
Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·A A De QueirozO Z Higa
Jul 11, 1998·Journal of Biomaterials Science. Polymer Edition·R Yoda
May 2, 2018·Physical Chemistry Chemical Physics : PCCP·Kang WangLei Shen
Nov 28, 2012·Advanced Healthcare Materials·Motoki InoueTetsushi Taguchi
Feb 1, 2019·Journal of Biomedical Materials Research. Part a·Kazuhiko Ishihara
Apr 9, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kara L Menzies, Lyndon Jones
Jan 5, 2006·European Journal of Anaesthesiology·A M RocheM G Mythen
May 10, 2006·Expert Review of Medical Devices·Dean Belway, Fraser D Rubens
Jul 31, 2013·Journal of Biomedical Materials Research. Part a·Bharat Bhushan, Scott R Schricker
Mar 1, 1988·Journal of Biomedical Materials Research·D W GraingerJ Feijen
Apr 1, 1995·Transfusion Medicine Reviews·A BruilW G van Aken

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.