Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.

Biomacromolecules
Semra ColakGregory N Tew

Abstract

Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).

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Citations

Jun 22, 2010·Applied Microbiology and Biotechnology·Edmund F Palermo, Kenichi Kuroda
Sep 7, 2013·Accounts of Chemical Research·Federica SgolastraGregory N Tew
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Dec 1, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Semra Colak, Gregory N Tew
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