Hydrophilic nanofibrous structure of polylactide; fabrication and cell affinity

Journal of Biomedical Materials Research. Part a
Shanta Raj BhattaraiHak Yong Kim

Abstract

Microstructure and architecture of the scaffolds along with the surface chemistry exert profound effect on biological activity (cell distribution, proliferation, and differentiation). For the biological activity, scaffolds in tissue engineering have been widely designed. The objective of this study was to develop hydrophilic nanofibrous structure of polylactides (PLLA) polymer in the form of nonwoven mat by electrospinning technique, and further evaluate the fibroblast NIH3T3 cell proliferation, morphology, and cell-matrix interaction. Hydrophilicity of the PLLA fibers was improved by adding small fraction of low molecular weight polyethylene glycol (PEG) into the electrospinning solution. Four different ratio types (100/0, 80/20, 70/30, and 50/50) of PLLA/PEG electrospun matrices were fabricated, and the pore characteristics, tensile properties, contact angle, and hydrolytic degradation were observed. Furthermore, scanning electron microscope (SEM) and fluorescence actin staining images were used for micro-observation of cell-matrix interaction and cell morphology. It was found that the electrospun mat of PLLA/PEG (80/20), composed of fibers with diameters in the range 540-850 nm, majority of pore diameter less than 100 microm...Continue Reading

References

Nov 1, 1989·Biomaterials·R MuzzarelliC Rizzoli
Nov 1, 1993·Journal of Neuroscience Methods·M MatsuzawaV Krauthamer
Mar 18, 1994·Science·R GrefR Langer
May 14, 1993·Science·R Langer, J P Vacanti
Jun 1, 1997·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·G KratzO Larm
Mar 21, 1998·Transplant Immunology·L E Niklason, R S Langer
Jun 11, 1998·Trends in Biotechnology·B S Kim, D J Mooney
Jun 1, 1995·Bio/technology·J A Hubbell
Dec 16, 1998·Journal of Colloid and Interface Science·J H LeeH B Lee
Jun 5, 1999·Journal of Biomedical Materials Research·P X Ma, R Zhang
Jul 9, 1999·Journal of Biomedical Materials Research·J H LeeY M Ju
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·V P ShastriR Langer
Jan 15, 2002·Journal of Biomaterials Science. Polymer Edition·L HuangE L Chaikof
Mar 13, 2002·Biomacromolecules·Jamil A MatthewsGary L Bowlin
Apr 12, 2002·Journal of Biomedical Materials Research·Wan-Ju LiFrank K Ko
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jing ZengXiabin Jing
Nov 5, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Myung-Seob KhilNarayan Bhattarai
Jan 31, 2004·Biomaterials·Shanta Raj BhattaraiHak Yong Kim

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Citations

May 23, 2009·Tissue Engineering. Part B, Reviews·Yixiang DongSeeram Ramakrishna
Jan 26, 2012·International Journal of Nanomedicine·Rajesh Vasita, Dhirendra S Katti
Jan 15, 2014·Tissue Engineering. Part B, Reviews·Kazunori ShimomuraNorimasa Nakamura
Jan 7, 2010·Acta Biomaterialia·Bernke J PapenburgDimitrios Stamatialis
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·John MohanrajAlessandro Fraleoni-Morgera
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Arijit BhattacharjeeDhirendra S Katti
Jul 22, 2008·Biomaterials·Sangamesh G KumbarCato T Laurencin
Apr 29, 2008·Biomaterials·David F Williams
Sep 22, 2007·Advanced Drug Delivery Reviews·Dehai LiangBenjamin Chu
Oct 25, 2007·Journal of Biomedical Materials Research. Part a·Shanta Raj BhattaraiHak Yong Kim
Sep 3, 2011·Journal of Biomedical Materials Research. Part a·Abbas ShafieeYousof Gheisari
Jun 15, 2012·Journal of Biomedical Materials Research. Part a·Chi MaChengdong Xiong
Nov 22, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tae-Sik JangYoung-Hag Koh
Nov 12, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jiang WuBo Gao
Apr 26, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xiaodong HouAmin Cao
Oct 14, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nisarg TambeMartin W King
Sep 16, 2016·Biomacromolecules·Luanda Chaves LinsJean-François Gérard
Dec 1, 2014·Progress in Biomaterials·Robin AugustineSabu Thomas
May 1, 2018·Biomedizinische Technik. Biomedical Engineering·Magnus KruseStefan Jockenhoevel
Jun 23, 2007·Angewandte Chemie·Andreas Greiner, Joachim H Wendorff
Feb 11, 2015·Journal of Materials Science. Materials in Medicine·Guang-Chang ZhuZhong-Gao Wang
Dec 1, 2020·Frontiers in Cell and Developmental Biology·George JacobNorimasa Nakamura
Feb 12, 2008·Biomacromolecules·Anna ThorvaldssonPernilla Walkenström
Apr 2, 2010·ACS Applied Materials & Interfaces·Shih-Po SunMontgomery T Shaw
Jun 8, 2021·Annual Review of Chemical and Biomolecular Engineering·Sung-Hyuk SunwooDae-Hyeong Kim
Jan 6, 2018·ACS Applied Materials & Interfaces·Uddalok SenConstantine M Megaridis
Dec 1, 2021·ACS Biomaterials Science & Engineering·Lisa TerranovaFlorent Meyer

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