Abstract
Gelatin contains many functional motifs which can modulate cell specific adhesion, so we modified polycarbonate urethane (PCU) scaffold surface by immobilization of gelatin. PCU-g-gelatin scaffolds were prepared by direct immobilizing gelatins onto the surface of aminated PCU scaffolds. To increase the immobilization amount of gelatin, poly(ethylene glycol) methacrylate (PEGMA) was grafted onto PCU scaffolds by surface initiated atom transfer radical polymerization. Then, following amination and immobilization, PCU-g-PEGMA-g-gelatin scaffolds were obtained. Both modified scaffolds were characterized by chemical and biological methods. After immobilization of gelatin, the microfiber surface became rough, but the original morphology of scaffolds was maintained successfully. PCU-g-PEGMA-g-gelatin scaffolds were more hydrophilic than PCU-g-gelatin scaffolds. Because hydrophilic PEGMA and gelatin were grafted and immobilized onto the surface, the PCU-g-PEGMA-g-gelatin scaffolds showed low platelet adhesion, perfect anti-hemolytic activity and excellent cell growth and proliferation capacity. It could be envisioned that PCU-g-PEGMA-g-gelatin scaffolds might have potential applications in tissue engineering artificial scaffolds.
References
Nov 1, 1987·Biomaterials·R GuidoinM Duval
Nov 1, 1985·Biomaterials·P B van WachemW G van Aken
Mar 15, 1997·Structure·A R PickfordI D Campbell
Aug 5, 1998·Biomaterials·F H LinC W Huang
Jul 4, 2001·Biomaterials·Y G KoD J Ahn
Jan 17, 2002·Biomaterials·Si-Nae ParkHwal Suh
Apr 16, 2003·Biomaterials·Alexander M SeifalianGeorge Hamilton
Jul 30, 2004·Biomaterials·Imran KhanRuth Elizabeth Cameron
Mar 21, 2007·Colloids and Surfaces. B, Biointerfaces·Xiao-Kun LiXiao-Bing Fu
Mar 30, 2010·Biomaterials·Yuxiao LaiJiandong Ding
Jul 21, 2010·Biomaterials·Lin WangRebecca L Carrier
Feb 22, 2011·Colloids and Surfaces. B, Biointerfaces·Yu WeiJian Ji
Aug 13, 2011·Colloids and Surfaces. B, Biointerfaces·Motoki InoueTetsushi Taguchi
Aug 20, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·H JiangJ Shen
Jan 17, 2012·Biomaterials·Wenting ZhengDeling Kong
Aug 14, 2012·Biomaterials·Jian YuSong Li
Aug 28, 2012·Biomaterials·Huanan WangSander C G Leeuwenburgh
Dec 19, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tianyuan CiJiandong Ding
Jul 19, 2013·Biomaterials·Costantino Del GaudioPaolo Macchiarini
Oct 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O Elzoghby
Citations
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Y ElsayedP Tomlins
Mar 30, 2016·International Journal of Biological Macromolecules·Tetsuya FuruikeHiroshi Tamura
Sep 17, 2015·ACS Applied Materials & Interfaces·Changcan ShiXiangkui Ren
May 26, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maria Martínez-IbáñezJoachim Kohn
Mar 28, 2018·Journal of Nanobiotechnology·Qian LiYakai Feng
May 30, 2015·Chemical Society Reviews·Xiangkui RenWenzhong Li
Sep 28, 2016·Macromolecular Rapid Communications·Timothy C BoireHak-Joon Sung
Sep 30, 2016·Macromolecular Rapid Communications·Jing YangWencheng Zhang
May 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ihsan UllahChangcan Shi
Aug 4, 2016·Journal of Biomaterials Science. Polymer Edition·Zhong-Kui LiSi-Ming Yan
Mar 25, 2015·Nanomaterials·Kedong SongTianqing Liu
Oct 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ZhaoChangcan Shi
Apr 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haixia WangWencheng Zhang
Jan 29, 2016·Polymers·Yakai FengWencheng Zhang
Oct 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing YangWencheng Zhang
May 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing YangWencheng Zhang
Aug 5, 2019·Acta Biomaterialia·Jing ZhaoYakai Feng
Oct 23, 2020·International Journal of Biological Macromolecules·Pejman Ghaffari-BohlouliMohsen Shahrousvand
Jun 3, 2021·Materials·Aleksandra KuźmińskaBeata A Butruk-Raszeja
May 27, 2015·ACS Applied Materials & Interfaces·Xuefang HaoWencheng Zhang
Jun 10, 2019·ACS Biomaterials Science & Engineering·Jing ZhaoYakai Feng
Jul 14, 2020·ACS Applied Bio Materials·Muhammad RizwanEvelyn K F Yim
Aug 9, 2019·ACS Applied Materials & Interfaces·Dongfang WangLih-Sheng Turng
Jul 14, 2018··Madana Leela NallappanMohamed Mahmoud Nasef