Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation

Materials Science & Engineering. C, Materials for Biological Applications
Changcan ShiWencheng Zhang

Abstract

Gelatin contains many functional motifs which can modulate cell specific adhesion, so we modified polycarbonate urethane (PCU) scaffold surface by immobilization of gelatin. PCU-g-gelatin scaffolds were prepared by direct immobilizing gelatins onto the surface of aminated PCU scaffolds. To increase the immobilization amount of gelatin, poly(ethylene glycol) methacrylate (PEGMA) was grafted onto PCU scaffolds by surface initiated atom transfer radical polymerization. Then, following amination and immobilization, PCU-g-PEGMA-g-gelatin scaffolds were obtained. Both modified scaffolds were characterized by chemical and biological methods. After immobilization of gelatin, the microfiber surface became rough, but the original morphology of scaffolds was maintained successfully. PCU-g-PEGMA-g-gelatin scaffolds were more hydrophilic than PCU-g-gelatin scaffolds. Because hydrophilic PEGMA and gelatin were grafted and immobilized onto the surface, the PCU-g-PEGMA-g-gelatin scaffolds showed low platelet adhesion, perfect anti-hemolytic activity and excellent cell growth and proliferation capacity. It could be envisioned that PCU-g-PEGMA-g-gelatin scaffolds might have potential applications in tissue engineering artificial scaffolds.

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Citations

Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Y ElsayedP Tomlins
Mar 30, 2016·International Journal of Biological Macromolecules·Tetsuya FuruikeHiroshi Tamura
Sep 17, 2015·ACS Applied Materials & Interfaces·Changcan ShiXiangkui Ren
May 26, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maria Martínez-IbáñezJoachim Kohn
Sep 28, 2016·Macromolecular Rapid Communications·Timothy C BoireHak-Joon Sung
Sep 30, 2016·Macromolecular Rapid Communications·Jing YangWencheng Zhang
May 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ihsan UllahChangcan Shi
Aug 4, 2016·Journal of Biomaterials Science. Polymer Edition·Zhong-Kui LiSi-Ming Yan
Oct 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ZhaoChangcan Shi
Apr 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haixia WangWencheng Zhang
Oct 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing YangWencheng Zhang
May 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing YangWencheng Zhang

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