Hydrophilic surface modification of acrylate-based biomaterials

Journal of Biomaterials Applications
M Arnal-PastorA Vallés-Lluch

Abstract

Acrylic polymers have proved to be excellent with regard to cell adhesion, colonization and survival, in vitro and in vivo. Highly ordered and regular pore structures thereof can be produced with the help of polyamide templates, which are removed with nitric acid. This treatment converts a fraction of the ethyl acrylate side groups into acrylic acid, turning poly(ethyl acrylate) scaffolds into a more hydrophilic and pH-sensitive substrate, while its good biological performance remains intact. To quantify the extent of such a modification, and be able to characterize the degree of hydrophilicity of poly(ethyl acrylate), poly(ethyl acrylate) was treated with acid for different times (four, nine and 17 days), and compared with poly(acrylic acid) and a 90/10%wt. EA/AAc copolymer (P(EA-co-AAc)). The biological performance was also assessed for samples immersed in acid up to four days and the copolymer, and it was found that the incorporation of acidic units on the material surface was not prejudicial for cells. This surface modification of 3D porous hydrophobic scaffolds makes easier the wetting with culture medium and aqueous solutions in general, and thus represents an advantage in the manageability of the scaffolds.

References

Dec 18, 2001·Journal of Biomedical Materials Research·Colin A ScotchfordSandra Downes
Jun 21, 2005·Journal of Materials Science. Materials in Medicine·R Brígido DiegoM Salmerón Sánchez
Jun 22, 2006·Journal of Biomedical Materials Research. Part a·José Miguel SoriaJuan Antonio Barcia
Jul 10, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·José Carlos Rodríguez HernándezManuel Monleón Pradas
Feb 15, 2011·Journal of Biomedical Materials Research. Part a·Jose Miguel SoriaCarmen Carda
May 17, 2011·PloS One·Virginia Llopis-HernándezManuel Salmerón-Sánchez
Jun 15, 2011·Journal of Colloid and Interface Science·M Arnal-PastorM Monleón Pradas
Jun 27, 2012·Journal of Biomedical Materials Research. Part a·Cristina Martínez-RamosManuel Monleón Pradas
Aug 13, 2013·Acta Biomaterialia·A Vallés-LluchM Monleón Pradas
Nov 13, 2013·Expert Review of Cardiovascular Therapy·Juan C ChachquesCarlos Semino
Mar 19, 2014·Tissue Engineering. Part C, Methods·Cristina Martínez-RamosManuel Monleón Pradas
Jan 20, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Jing Zhong LukLisbeth Grøndahl

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy
infrared spectroscopy

Software Mentioned

Statgraphics Centurion

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.