PMID: 8956078Nov 1, 1996Paper

Hydrophobic distribution and spatial arrangement of amino acid residues in membrane proteins

International Journal of Peptide and Protein Research
M M Gromiha, P K Ponnuswamy

Abstract

The analysis of known three-dimensional structures of membrane proteins provides an opportunity to understand their structure and stability. In this article we analyse the hydrophobic variation of amino acid residues at various ranges in membrane and aqueous parts of membrane proteins. The numerical indices for several properties of amino acid residues in membrane proteins, such as surrounding hydrophobicity, gain in surrounding hydrophobicity, hydrophobic gain ratio, accessible surface area, preference of amino acid residues in the interior and surface parts, solvent accessible reduction ratio and buriedness, were set up. The relative preference of amino acid residues at various positions of membrane proteins were obtained in a very realistic approach.

References

Dec 1, 1977·Archives of Biochemistry and Biophysics·P Manavalan, P K Ponnuswamy
Mar 15, 1978·Journal of Molecular Biology·T J Richmond, F M Richards
Oct 19, 1978·Nature·P Manavalan, P K Ponnuswamy
Jul 25, 1976·Journal of Molecular Biology·C Chothia
Sep 20, 1992·Journal of Molecular Biology·M S Weiss, G E Schulz
Apr 1, 1992·Protein Engineering·M SchifferF J Stevens
Dec 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W A CramerD C Rees
Mar 29, 1991·Biochemical and Biophysical Research Communications·D N WoolfsonD H Williams
Jan 1, 1991·Journal of Bacteriology·J StoorvogelJ A van de Klundert
Apr 5, 1991·Journal of Molecular Biology·G von Heijne
Jan 1, 1990·Biopolymers·C M DeberG A Woolley
May 31, 1990·European Journal of Biochemistry·M Degli EspostiG Venturoli
Nov 5, 1988·Journal of Molecular Biology·J JaninC Chothia
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·D M EngelmanA Goldman
May 28, 1985·Biochimica Et Biophysica Acta·P KleinC DeLisi
Apr 29, 1985·Biochimica Et Biophysica Acta·L A Kuhn, J S Leigh
Aug 30, 1985·Science·G D RoseM H Zehfus
Feb 14, 1971·Journal of Molecular Biology·B Lee, F M Richards
Nov 15, 1982·European Journal of Biochemistry·P ArgosP A Hargrave
May 15, 1981·European Journal of Biochemistry·G von Heijne
Jun 26, 1980·Biochimica Et Biophysica Acta·P K PonnuswamyP Manavalan
Nov 1, 1993·International Journal of Peptide and Protein Research·M M Gromiha, P K Ponnuswamy
Feb 21, 1994·FEBS Letters·D T JonesJ M Thornton
Oct 1, 1993·International Journal of Peptide and Protein Research·P K Ponnuswamy, M M Gromiha
Jan 1, 1993·Progress in Biophysics and Molecular Biology·P K Ponnuswamy

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Citations

Nov 14, 2006·Journal of Bioinformatics and Computational Biology·Nataliya S SadovskayaMikhail S Gelfand
Jun 28, 2001·Preparative Biochemistry & Biotechnology·T S KumarevelM N Ponnuswamy
Jun 12, 2010·Biological Chemistry·Petra Van DammeKris Gevaert
Jun 28, 2001·Preparative Biochemistry & Biotechnology·M M Gromiha
Aug 4, 2004·Progress in Biophysics and Molecular Biology·M Michael Gromiha, S Selvaraj
Sep 28, 1998·Biophysical Chemistry·T S KumarevelM N Ponnuswamy
Jun 29, 2001·International Journal of Biological Macromolecules·M M Gromiha, S Selvaraj
Sep 6, 2003·International Journal of Biological Macromolecules·M Michael Gromiha, Makiko Suwa

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