Hydrophobic moments, shape, and packing in disordered proteins

The Journal of Physical Chemistry. B
Nidhi Rawat, Parbati Biswas

Abstract

Disordered proteins play a significant role in many biological processes and provide an attractive target for biophysical studies under physiological conditions. Disordered proteins may be classified as (a) proteins with overall well-defined secondary structures, interspersed with regions of missing residues, or (b) natively unstructured proteins which lack definite secondary structure. The spatial profile of second order hydrophobic moment for disordered proteins depicts the distribution of hydrophobic residues from the interior to the surface of the protein and indicates the lack of a well-formed hydrophobic core unlike that of the globular proteins. This trend is independent of the size or position of the disordered region in the sequence. The hydrophobicity profile of the ordered regions of the disordered proteins differ considerably from that of globular proteins implying the role of disordered parts and the significance of hydrophobic interactions in the folding of proteins. The shape asymmetry of the two classes of disordered proteins is determined by calculating the asphercity and shape parameters, derived from the cartesian components of radius of gyration tensor. Disordered proteins of group a are more spherical as co...Continue Reading

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Nov 10, 2009·The Journal of Chemical Physics·Nidhi Rawat, Parbati Biswas

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Citations

Mar 22, 2013·PloS One·Dan V NicolauDan V Nicolau
Aug 12, 2014·Biochimica Et Biophysica Acta·Pooja RaniParbati Biswas
Nov 26, 2015·Journal of Molecular Biology·Yin TangPhilip C Bevilacqua
Feb 28, 2014·The Journal of Physical Chemistry. B·Nidhi Rawat, Parbati Biswas
Jul 12, 2016·International Journal of Molecular Sciences·Mihai V PutzSperanta Avram
Jan 18, 2018·Proteins·Rasim Murat Aydinkal, Elife Zerrin Bagci
Feb 17, 2017·The Journal of Chemical Physics·Adesh KumarParbati Biswas
Jan 6, 2021·European Biophysics Journal : EBJ·Adriana E MieleMaria Carmela Bonaccorsi di Patti
Mar 20, 2018·The Journal of Physical Chemistry. B·Leena Aggarwal, Parbati Biswas

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