Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute

Biomaterials
Rajesh K KainthanDonald E Brooks

Abstract

There is a huge clinical demand for Human Serum Albumin (HSA), with a world market of approximately $1.5B/year. Concern over prion and viral transmission in the blood supply has led to a need for safer substitutes and offers the opportunity for development of materials with enhanced properties over the presently available plasma expanders. We report here the synthesis and testing of a new synthetic plasma expander that can replace not only the osmotic and volume expansion properties of HSA but, uniquely, its binding and transport properties. We have synthesized several hyperbranched polyglycerols derivatized with hydrophobic groups and short poly(ethylene glycol) (PEG) chains. The hydrophobic groups provide regions for binding fatty acids and other hydrophobic materials while PEG imparts the necessary protection from host defense systems and enhances circulation longevity. These polymers, being hyperbranched, have only a small effect on plasma viscosity. We have shown in vitro that our materials bind 2-3 moles palmitic acid per mole, do not activate the platelet, coagulation or complement systems and do not cause red cell aggregation. In mice these materials are non-toxic with circulation half-lives as high as 34h, controllable...Continue Reading

References

Dec 1, 1993·Blood Reviews·M G MythenA R Webb
Jan 1, 1997·Journal of Clinical Apheresis·M E BrecherN Bandarenko
May 6, 1999·Intensive Care Medicine·J TreibR G Strauss
Sep 13, 2000·International Journal of Clinical Pharmacology and Therapeutics·D H BremerichM Behne
Jun 8, 2001·Critical Care Medicine·E de Jonge, M Levi
Feb 5, 2003·Advanced Drug Delivery Reviews·Richard B GreenwaldCharles D Conover
May 12, 2004·Archives of Surgery·Michael E BarronRoberta J Navickis
Sep 14, 2004·Biophysical Journal·J K ArmstrongT C Fisher
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gregory J QuinlanTimothy W Evans
Oct 26, 2005·Drug Discovery Today·Francesco M Veronese, Gianfranco Pasut
Mar 15, 2006·Biomacromolecules·Rajesh Kumar KainthanDonald E Brooks
May 26, 2006·European Journal of Anaesthesiology·I J Davidson
Aug 11, 2007·Biomaterials·Rajesh Kumar KainthanDonald Elliott Brooks
Aug 21, 2007·Biomaterials·Rajesh K Kainthan, Donald E Brooks

❮ Previous
Next ❯

Citations

Feb 7, 2012·Bioconjugate Chemistry·Katayoun SaatchiUrs O Häfeli
Apr 17, 2012·Bioconjugate Chemistry·Marya AhmedRavin Narain
Jan 26, 2013·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Asher A MendelsonCaigan Du
Mar 20, 2012·Nature Materials·Xifei YuDonald E Brooks
Feb 17, 2009·Expert Opinion on Biological Therapy·Katsuhiko ArigaGuoping Chen
Oct 21, 2015·Advanced Materials·Yi JiaJunbai Li
Oct 21, 2015·Journal of Biomedical Materials Research. Part a·Qian HuWei Xue
Feb 24, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zonghua LiuWei Xue
Jun 10, 2015·Molecular and Cellular Therapies·Jasmine L Hamilton, Jayachandran N Kizhakkedathu
Jan 22, 2014·Macromolecular Bioscience·Florian PaulusRainer Haag
Jul 22, 2014·Macromolecular Bioscience·Muhammad Imran ul-haqJayachandran N Kizhakkedathu
Mar 11, 2010·Advanced Materials·Marcelo CalderónRainer Haag
Nov 18, 2014·Macromolecular Rapid Communications·Meena KumariRainer Haag
Feb 11, 2015·Biomacromolecules·Prashant KumarSuzana K Straus
Sep 2, 2014·Chemical Society Reviews·Dali WangWenxin Wang
Oct 30, 2018·Journal of Cellular Physiology·Narges FereydouniAmirhossein Sahebkar
Dec 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Srinivas AbbinaJayachandran N Kizhakkedathu
Mar 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei ZhangWei Xue
Dec 5, 2013·Pharmaceutics·Okhil K Nag, Vibhudutta Awasthi
Oct 25, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shadan LiCaigan Du
Mar 2, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Clement MugabeHelen M Burt
Jan 8, 2021·Chemistry and Physics of Lipids·Mehak RastogiSunil Kumar Dubey
Dec 25, 2019·International Journal of Pharmaceutics·Mahboobeh JafariAli Mohammad Tamaddon
Oct 14, 2008·Bioconjugate Chemistry·Rajesh Kumar Kainthan, Donald E Brooks
Sep 2, 2010·Biomacromolecules·Jayachandran N KizhakkedathuCharles A Haynes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.