PMID: 9438357Jan 1, 1997Paper

Hydrophobicity and outer membrane proteins of Shigella dysenteriae type 1 after treatment with subinhibitory concentrations of aminoglycosides

Folia Microbiologica
A Hostacká, E Karelová

Abstract

Hydrophobicity and profiles of outer membrane proteins of Shigella dysenteriae type 1 after treatment with subinhibitory concentrations (1/2 or 1/4 of the MIC) of aminoglycosides were studied. The antimicrobial activity of the antibiotics tested was 3.12 mg/L (amikacin, tobramycin) and 6.25 mg/L (gentamicin). The hydrophobicity of the cell surface of S. dysenteriae type 1 was decreased after exposure to all aminoglycosides at a concentration of 1/2 of the MICs; 1/4 of the MICs of the antibiotics did not affect bacterial aggregation in the presence of ammonium sulfate. SDS-polyacrylamide gel electrophoresis showed that the profiles of outer membrane proteins of the strain treated with aminoglycosides at both subinhibitory concentrations were not changed as compared to the control.

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Citations

May 19, 2000·Microbes and Infection·R J Doyle

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