Hydrops fetalis associated with homozygosity for hemoglobin Taybe (alpha 38/39 THR deletion) in newborn triplets

American Journal of Hematology
Shmuel ArnonL Jaber

Abstract

Hemoglobin Taybe is an unstable alpha-chain hemoglobin variant caused by a deletion of a threonine residue at codon 38 or 39 of the alpha-1 globin chain. We describe preterm infant triplets born with hydrops fetalis and anemia who were found by DNA analysis to be homozygous for hemoglobin Taybe. All three infants developed intrauterine hemolytic anemia, which subsequently led to hydrops fetalis. To the best of our knowledge, this is the first description of hydrops fetalis associated with this hemoglobinopathy. We suggest that hemoglobin Taybe be considered in the differential diagnosis of hydrops fetalis and that known affected fetuses be carefully followed both antenatally and postnatally.

Citations

Dec 14, 2006·Journal of Pediatric Hematology/oncology·Pimlak CharoenkwanTorpong Sanguansermsri
Nov 28, 2012·Hemoglobin·Maja Bech JuulHenrik Frederiksen
Mar 21, 2012·Hemoglobin·Maria Elisabetta PagliettiRenzo Galanello
Aug 13, 2005·Annals of Human Biology·David H K Chui
Jul 23, 2008·Prenatal Diagnosis·Can LiaoDong-Zhi Li
Dec 13, 2005·Annals of the New York Academy of Sciences·David H K Chui
Sep 4, 2015·Journal of Pediatric Hematology/oncology·Lutfi Jaber, Gary Diamond
Jul 21, 2010·Hemoglobin·Ita M NainggolanIswari Setianingsih
Nov 1, 2015·European Journal of Haematology·Ariel KorenMichael Bennett

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