PMID: 6977515Feb 1, 1982Paper

Hydroquinone and catechol reduce the frequency of progenitor B lymphocytes in mouse spleen and bone marrow

Immunopharmacology
D Wierda, R D Irons

Abstract

Hydroquinone and catechol are two metabolites of benzene that are potential inducers of hematotoxicity. We investigated the in vivo toxicity of these metabolites toward the development of polyclonal, plaque-forming cells (PC-PFC) from progenitor B lymphocytes. Dextran sulfate (DxS), lipopolysaccharide (LPS), or the two mitogens combined (DxS + LPS) were used to induce proliferation and maturation of these progenitors to PC-PFC. Groups of 4 C57BL/6 mice were exposed to 2 daily doses, either intravenously or intraperitoneally, of hydroquinone (100 mg/kg) or catechol (75 mg/kg) for 3 consecutive days. Spleen and marrow cells were harvested for culture 1 day later. The results demonstrated that both metabolites were cytotoxic to spleen cells. Hydroquinone (100 mg/kg) also reduced marrow cellularity, whereas catechol (75 mg/kg) did not significantly affect marrow cellularity. Each compound reduced the frequency of PC-PFC developed from the spleens and marrows of treated mice, but only catechol selectively inhibited the maturation of LPS-activated marrow progenitors into end-stage PC-PFC. These experiments demonstrate the immunotoxic potential of hydroquinone and catechol in vivo through the reduction of progenitor B lymphocytes and ...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·C BonaR G Miller
Mar 1, 1979·The Journal of Experimental Medicine·J AnderssonF Melchers
May 1, 1977·European Journal of Immunology·A CoutinhoT Watanabe
Mar 1, 1978·The American Journal of the Medical Sciences·H S CohenB D Goldstein
Jan 1, 1979·Journal of Immunopharmacology·D Wierda, T L Pazdernik
Dec 15, 1977·Life Sciences·R SnyderC M Witmer
Apr 1, 1977·Toxicology and Applied Pharmacology·E M UyekiT U Bisel
Jul 1, 1977·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J A Timbrell, J R Mitchell
Jan 1, 1976·Scandinavian Journal of Immunology·E GronowiczA Coutinho
Jun 1, 1975·CRC Critical Reviews in Toxicology·R Snyder, J J Kocsis
Oct 1, 1974·European Journal of Immunology·F Melchers, J Andersson
Nov 1, 1974·European Journal of Immunology·E Gronowicz, A Coutinho
Feb 1, 1974·Toxicology and Applied Pharmacology·E W LeeR Snyder
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Jun 30, 1981·Toxicology and Applied Pharmacology·W F GreenleeJ S Bus
Oct 1, 1980·Archives of Toxicology·R D Irons, D A Neptun

❮ Previous
Next ❯

Citations

Mar 1, 1988·Archives of Environmental Contamination and Toxicology·G C HsiehR D Parker
Jan 1, 1993·Molecular Aspects of Medicine·R Burrell
Oct 1, 1985·Immunopharmacology·R W Pfeifer, R M Patterson
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R D IronsV A Henry
Oct 28, 2006·Toxicologic Pathology·Gregory S Travlos
Jul 1, 1989·Environmental Health Perspectives·D L LaskinR Snyder
Jan 1, 1985·Journal of Toxicology and Environmental Health·R D Irons
Jun 20, 2002·Critical Reviews in Toxicology·Robert Snyder
Jun 24, 1999·Critical Reviews in Toxicology·A P DeCaprio
Jun 1, 1990·Ecotoxicology and Environmental Safety·J DevillersD Dive
Oct 1, 1984·Toxicology and Applied Pharmacology·K Gaido, D Wierda
Sep 30, 1985·Toxicology and Applied Pharmacology·G J Rosenthal, C A Snyder
Jan 1, 1987·Critical Reviews in Toxicology·G F Kalf
Jan 15, 2009·Toxicology and Industrial Health·J DahlgrenH Takhar
Mar 30, 1987·Toxicology and Applied Pharmacology·G J Rosenthal, C A Snyder
Jan 1, 1985·Journal of Immunopharmacology·R W Pfeifer, R M Patterson
Dec 17, 1997·Toxicology and Industrial Health·G L Gist, J R Burg
Jul 24, 2021·Health Science Reports·Verónica Ramírez-LoperaTania Liseth Pérez-Cala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.