Hydroxyapatite and fluor-hydroxyapatite layered film on titanium processed by a sol-gel route for hard-tissue implants

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Hae-Won KimHyoun-Ee Kim

Abstract

A double-layered coating, consisting of a hydroxyapatite (HA) outer film and a fluor-hydroxyapatite (FHA) inner film, was produced on a Ti substrate by a sol-gel route to improve the biocompatibility and functionality of the system. Dissolution behavior of and in vitro cellular responses to the layered film were investigated. Calcium nitrate and triethyl phosphite were used for calcium and phosphate precursors, respectively, and ammonium fluoride was added as a fluorine-ion source for FHA. The FHA layer was deposited on Ti by spin coating and subsequent heat treatment at 550 degrees C for 30 min in air, and then the HA layer was laid down over the FHA-coated Ti under the same conditions. After heat treatment, characteristic apatite structures and phases were developed on both FHA and HA films. The cross-section view of the HA/FHA film clearly showed a double-layered structure on Ti with each layer approximately 0.6-0.8-microm thickness. The coating layer was highly uniform and dense, and adhered to Ti substrate strongly with an adhesion strength of about 40 MPa. The in vitro solubility of the HA/FHA layered film in a physiological solution was between that of HA and FHA pure film, and the dissolution profile was quite biphasic,...Continue Reading

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Citations

Oct 3, 2012·International Journal of Nanomedicine·Lu XiaRong Yu
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Sergey V Dorozhkin
Dec 12, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Christopher J TredwinJonathan C Knowles
Jan 10, 2008·Acta Biomaterialia·Chengtie WuHala Zreiqat
Mar 29, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Anna ArvidssonVictoria Franke Stenport
Mar 28, 2013·Journal of Biomedical Materials Research. Part a·Ping YinXin Chun Jian
Apr 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona Liliana IconaruDaniela Predoi
Dec 21, 2005·Journal of Biomaterials Applications·Su-Hee LeeHyoun-Ee Kim
Jun 28, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Young-Min KongHae-Won Kim
Jul 20, 2007·Journal of Biomedical Materials Research. Part a·Yongsheng WangMin Qian
Jun 25, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hong Mi KimInn-Kyu Kang
Aug 18, 2005·Journal of Biomedical Materials Research. Part a·Hae-Won KimHyoun-Ee Kim
Aug 19, 2005·Journal of Biomedical Materials Research. Part a·Hae-Won KimHyoun-Ee Kim
Nov 10, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hae-Won Kim, Hyoun-Ee Kim
Dec 26, 2006·Expert Review of Medical Devices·Javad ParviziIrving M Shapiro
Jan 25, 2005·Journal of Biomedical Materials Research. Part a·Hae-Won KimHyoun-Ee Kim

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