Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid

Journal of the Royal Society, Interface
M TavafoghiM Cerruti

Abstract

Hydroxyapatite (HA, Ca5(PO4)3OH) is the main inorganic component of hard tissues, such as bone and dentine. HA nucleation involves a set of negatively charged phosphorylated proteins known as non-collagenous proteins (NCPs). These proteins attract Ca(2+) and PO4(3-) ions and increase the local supersaturation to a level required for HA precipitation. Polar and charged amino acids (AAs) are highly expressed in NCPs, and seem to be responsible for the mineralizing effect of NCPs; however, the individual effect of these AAs on HA mineralization is still unclear. In this work, we investigate the effect of a negatively charged (Glu) and positively charged (Arg) AA bound to carboxylated graphene oxide (CGO) on HA mineralization in simulated body fluids (SBF). Our results show that Arg induces HA precipitation faster and in larger amounts than Glu. We attribute this to the higher stability of the complexes formed between Arg and Ca(2+) and PO4(3-) ions, and also to the fact that Arg exposes both carboxyl and amino groups on the surface. These can electrostatically attract both Ca(2+) and PO4(3-) ions, thus increasing local supersaturation more than Glu, which exposes carboxyl groups only.

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Citations

Oct 7, 2016·Journal of the Royal Society, Interface·M Tavafoghi, M Cerruti
Jan 26, 2021·Frontiers in Cell and Developmental Biology·Jaepyo JeonMichael X Zhu
Feb 23, 2020·International Journal of Biological Macromolecules·Shadpour Mallakpour, Mohaddeseh Abbasi
Aug 10, 2021·Colloids and Surfaces. B, Biointerfaces·Maryam TavafoghiMaria Dittrich
Nov 27, 2018·ACS Applied Materials & Interfaces·Chuchao ZhouZhenxing Wang

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