Hydroxyapatite particles as drug carriers for proteins

Colloids and Surfaces. B, Biointerfaces
Keishiro TomodaKimiko Makino

Abstract

Recently, much attention has been paid to hydroxyapatite (HA) particles as protein drug carriers. HA is biological substance like tooth and bone, and HA has biodegradable and biocompatible property. Also HA has high affinity for versatile substances, such as proteins. The aim of this study was to prepare HA particles and to evaluate the effects of various experimental conditions on particles properties (i.e. shape and amount of protein adsorption to HA). HA particles were prepared by three methods including solvent diffusion methods, the method using sintering porous HA microgranules, and homogeneous precipitation method. Complicated spiky crystals were prepared by solvent diffusion method, whereas spherical amorphous agglomerates were prepared by sintering of porous HA granules. Spherical particles were obtained by homogeneous precipitation method and were well dispersed. The spherical particles were composed of minute spiky crystals. The temperature and time duration of the producing process and the amount of additives, such as urea and EDTANa(2), strongly affected the particle shape and size. When the production process is kept under low temperature, tiny crystals were not mutually sintered and also their aggregation was not...Continue Reading

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Citations

Apr 17, 2012·Journal of Drug Delivery·Chie Kojima, Kenji Watanabe
Sep 21, 2015·Colloids and Surfaces. B, Biointerfaces·Yuuka FukuiKeiji Fujimoto
Jan 30, 2013·Journal of Biomedical Materials Research. Part a·Gry Hulsart-BillströmZsombor Lacza
Nov 10, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vuk Uskoković, Dragan P Uskoković
Jan 1, 2010·Journal of Functional Biomaterials·Sergey V Dorozhkin
Apr 27, 2018·Physical Chemistry Chemical Physics : PCCP·Alexandra LoukaClaudio Luchinat
Mar 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jongman Lee, Hui-Suk Yun
Sep 6, 2013·Materials·Sergey V Dorozhkin
May 10, 2017·Acta Biomaterialia·Masahiro OkadaTakuya Matsumoto
Feb 17, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Rune A HartvigHenrik Jensen

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