Hydroxychloroquine and antiphospholipid antibody-related pregnancy morbidity: a systematic review and meta-analysis.

Current Opinion in Obstetrics & Gynecology
Margreta FrishmanKaren Schreiber

Abstract

Pregnancies in women with antiphospholipid antibodies (aPL) are associated with several pregnancy complications. The current treatment to prevent obstetric aPL-mediated morbidity is largely based on low-dose aspirin (LDA) and low-molecular-weight heparin (LMWH). Alternative treatment regimens to prevent obstetric aPL-related morbidity include the addition of the antimalarial hydroxychloroquine (HCQ). The aim of this systematic review is to identify the currently available evidence on the efficacy of HCQ to prevent aPL-related obstetric morbidity. We identified four retrospective observational studies. No definite signal of harm was identified as none of the studies reported adverse outcomes. When comparing a total of 214 aPL-positive women with a total of 250 HCQ-exposed aPL-positive pregnancies and 521 pregnancies not exposed to HCQ, we found that HCQ exposure was not associated with an increased rate of live births [pooled OR 1.33; 95% confidence interval (CI) 0.62--2.86]). There was considerable heterogeneity in the analysis (I = 59%). HCQ seems well tolerated in pregnancy. However, because of the heterogeneity of available studies, the questions whether women with aPL (or some subpopulation of those) might benefit from this...Continue Reading

References

Jan 27, 2015·Autoimmunity Reviews·Arsène MekinianUNKNOWN SNFMI and the European Forum on Antiphospholipid Antibodies
Oct 3, 2015·American Journal of Obstetrics and Gynecology·S SciasciaM J Cuadrado
Jan 12, 2016·Rheumatology·Julia FlintUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Jul 28, 2016·The Journal of Clinical Investigation·Eleftheria LefkouGuillermina Girardi
Mar 24, 2017·Obstetrics and Gynecology·Jessica M PageRobert M Silver
Jan 26, 2018·Nature Reviews. Disease Primers·Karen SchreiberBeverley J Hunt
May 17, 2019·Annals of the Rheumatic Diseases·Maria G TektonidouMichael M Ward

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jamilya KhizroevaTamara Mashkova
La Revue de médecine interne
Nathalie Costedoat-ChalumeauJ-C Piette
© 2021 Meta ULC. All rights reserved