Hydroxychloroquine and Chloroquine in COVID-19: A Survey of Prescription Patterns Among Rheumatologists.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Bella MehtaSaid Ibrahim

Abstract

With hydroxychloroquine (HCQ) and chloroquine (CQ) emerging as potential therapies for coronavirus disease 2019 (COVID-19), shortages have been reported. We aimed to understand how rheumatologists, one of the most common prescribers of HCQ/CQ, prescribed these medications to manage COVID-19 and to understand if their patients are affected by shortages. Between April 8 and April 27, 2020, an online survey was distributed to a convenience sample of rheumatologists who practice medicine in a diverse range of settings globally, resulting in 506 responses. Adjusted Poisson regression models were calculated. Only 6% of respondents prescribed HCQ/CQ for COVID-19 prophylaxis, and only 12% for outpatient treatment of COVID-19. Compared to the United States, the likelihood of prescribing HCQ/CQ for prophylaxis was higher in India (adjusted risk ratio [aRR], 6.7; 95% confidence interval [CI], 2.7-16.8; p < 0.001). Further, compared to the United States and those with 1 to 5 years of experience, rheumatologists in Europe (aRR, 2.9; 95% CI, 1.6-5.3; p < 0.001) and those with 10+ years of experience (11-20 years: aRR, 2.5; 95% CI, 1.2-5.3; p = 0.015; 21+ years: aRR = 3.3; 95% CI, 1.4-7.4; p = 0.004) had a higher likelihood of prescribing HCQ...Continue Reading

References

Feb 16, 2005·Annals of Internal Medicine·Niteesh K ChoudhryStephen B Soumerai
Mar 25, 2020·International Journal of Antimicrobial Agents·Philippe GautretDidier Raoult
Apr 1, 2020·Annals of Internal Medicine·Alfred H J KimUNKNOWN COVID-19 Global Rheumatology Alliance
Apr 2, 2020·Annals of Internal Medicine·Jinoos Yazdany, Alfred H J Kim
Apr 21, 2020·The Lancet Rheumatology·Milena A GianfrancescoUNKNOWN COVID-19 Global Rheumatology Alliance Steering Committee

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