Hydroxychloroquine in patients with systemic lupus erythematosus with end-stage renal disease

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Monique BethelLaura D Carbone

Abstract

To determine dosing patterns and examine predictors of filled hydroxychloroquine (HCQ) prescriptions in patients with systemic lupus erythematosus (SLE) with end-stage renal disease (ESRD). This was a retrospective cohort study of patients with SLE in the US Renal Data System (USRDS) database in fiscal year 2011. All patients were Medicare Part D beneficiaries. Patients with a diagnosis of SLE were identified by the International Classification of Diseases, 9th revision code 710. The prevalence, dosing, and predictors of filled HCQ prescriptions (demographic factors, dialysis type, and provider subspecialty) were determined. There were 10,276 patients with SLE identified; 2048 (19.9%) had a prescription for HCQ filled. The mean daily dose of HCQ was 321 mg (range 58-2000 mg). The most common daily doses were 200 (n=768, 37.5%) and 400 mg (n=1161, 56.7%). In multivariable logistic regression analysis, significant predictors of filled HCQ prescriptions included black/African-American race (OR 1.34, 95% CI (1.17 to 1.46)), hemodialysis (1.50, 95% CI (1.29 to 1.74)), and care from a rheumatologist (5.06, 95% CI (4.56 to 5.62)). Negative predictors of filled HCQ prescriptions included male gender (OR 0.72, 95% CI (0.63 to 0.83)) and...Continue Reading

Citations

Mar 11, 2017·Eye·I H YusufS M Downes
Apr 20, 2018·BMJ Case Reports·Ahmed El-SoliaAbdullah K Ai-Hwiesh
Jul 23, 2020·Therapeutics and Clinical Risk Management·Mahtabalsadat MirjaliliAfsaneh Vazin
Feb 9, 2020·Nature Reviews. Rheumatology·Eva Schrezenmeier, Thomas Dörner
Sep 25, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alessio GasperettiGiovanni Battista Forleo
Nov 17, 2020·Frontiers in Medicine·Richard B AguilarMarlow B Hernandez

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