Oct 14, 1988

Hydroxychloroquine treatment of rheumatoid arthritis

The American Journal of Medicine
R I Rynes

Abstract

A variety of placebo-controlled and open studies have demonstrated the effectiveness of hydroxychloroquine in the treatment of rheumatoid arthritis. The excellent responses to recurrent treatment in a sample patient illustrate the value of hydroxychloroquine. Because low daily doses of hydroxychloroquine are associated with greater ophthalmologic safety, it would be advantageous to use the smallest effective daily dose, but there are no published controlled efficacy studies using daily doses of less than 400 mg. Hydroxychloroquine may best be employed to treat patients with new onset of disease or those in whom disease is not rapidly progressive. Great potential exists for the use of hydroxychloroquine in combination therapy, but optimal utilization of combination regimens will require performances of additional controlled studies.

  • References7
  • Citations9

Mentioned in this Paper

Hydroxychloroquine
Ophthalmology Specialty
Anti-Inflammatory Agents
Plaquenil
Polychemotherapy
Rheumatoid Arthritis
Clinical Trials
Drug Administration Schedule

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