Hydroxyethyl starch-based polymers for the controlled release of biomacromolecules from hydrogel microspheres

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Stefanie Wöhl-BruhnHeike Bunjes

Abstract

Hydrogels are promising delivery systems for the controlled release of biomacromolecules. Based on previous studies, hydrogels were prepared from crosslinkable hydroxyethyl starch with new linker groups to improve mechanical and release properties of the resulting hydrogels. Polyethylene glycol methacrylate with two different spacer lengths was used to obtain polymers (HES-P(EG)(n)MA) with increased hydrophilicity and degradability, whereas a polymer with methacrylate linker directly at the starch backbone (HES-MA) resulted in a less degradable polymer. Hydrogel disks were obtained by UV crosslinking and characterized by swelling and rheological measurements. The hydrogel strength was strongly influenced by the polymer concentration. Using a water-in-water emulsion process, hydrogel microspheres were prepared. The influence of the type of the linker, the degree of substitution and the phase ratio in the production process on the properties of the microspheres was investigated. Depending on the preparation parameters, particles with narrow particle size distribution and encapsulation efficiencies of up to more than 80% for FITC-dextran 70 kDa (FD70) were obtained. Incorporated FITC-labeled IgG showed a faster release from hydrog...Continue Reading

References

Apr 1, 1997·Journal of Pharmaceutical Sciences·W N van Dijk-WolthuisW E Hennink
Jun 11, 1999·International Journal of Pharmaceutics·R J StenekesW E Hennink
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N A PeppasH Ichikawa
Jan 5, 2002·Advanced Drug Delivery Reviews·Allan S Hoffman
Sep 12, 2008·Biotechnology Letters·Snjezana Stolnik, Kevin Shakesheff
Aug 18, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ariane D A SchwoererRolf Daniels

❮ Previous
Next ❯

Citations

Dec 17, 2014·Pharmacology Research & Perspectives·T M GoszczyńskiJ Boratyński
Jun 13, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stefanie Wöhl-BruhnHeike Bunjes
Apr 27, 2013·Carbohydrate Polymers·Stefan HoffmannKarsten Mäder
Apr 10, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Stefanie Wöhl-BruhnHeike Bunjes
Sep 24, 2013·Carbohydrate Polymers·Mohammad Reza Vakili, Nahid Rahneshin
Jan 21, 2015·Critical Reviews in Food Science and Nutrition·Touseef Ahmed WaniMudasir Ahmad Shagoo
Aug 11, 2016·Food Chemistry·Negar AbhariOzra Hosseini Naveh
Mar 8, 2017·ACS Applied Materials & Interfaces·Chan YuXiangliang Yang
Jun 21, 2020·Polymers·Camilla NoèMinna Hakkarainen
Jun 18, 2021·ACS Biomaterials Science & Engineering·M Isabel Rial-HermidaJoão F Mano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Stefanie Wöhl-BruhnHeike Bunjes
Journal of Controlled Release : Official Journal of the Controlled Release Society
Stefanie Wöhl-BruhnHeike Bunjes
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Ariane SchwoererRolf Daniels
© 2021 Meta ULC. All rights reserved