Hydroxyethyl starch (HES) does not directly affect renal function in patients with no prior renal impairment

Journal of Clinical Anesthesia
M G DehneG Hempelmann

Abstract

To examine the effects of hydroxyethyl starch (HES) on renal function. Randomized, controlled trial. Operating theatre of a university hospital. 60 ASA physical status I and II male patients undergoing middle ear surgery. Patients received either lactated Ringer's solution (LRS) or one of three HES solutions. The HES solutions were administered in a dose of 15 mL/kg bodyweight (bw), the Ringer's solution in a dose of 60 mL/kg bw, after induction of anesthesia over a period of one hour. Blood and urine samples for hormone and enzyme tests were obtained at defined times before, during, and after surgery. Urine excretion, glomerular filtration rate (GFR), renal plasma flow, and routine hemodynamic parameters were measured simultaneously. There were no significant intergroup differences regarding GFR, renal plasma flow, or tubular and glomerular integrity as measured by specific proteins and enzymes (alpha-1-microglobulin, Tamm-Horsfall-protein, immunoglobulin G, and N-acetyl-beta-D-glucosaminidase). Arginine vasopressin decreased in all groups during and following anesthesia, aldosterone and plasma renin activity decreased only in the HES groups, and angiotensin II decreased only in the HES 200/0.5 group. Central venous pressure i...Continue Reading

References

Oct 1, 1992·Journal of Cardiovascular Pharmacology·M N SharifT W Wilson
Apr 1, 1990·The Annals of Thoracic Surgery·M HynynenJ Heinonen
Jun 1, 1990·Kidney International·S Kumar, A Muchmore
Jan 1, 1990·American Journal of Nephrology·J E Scherberich
May 1, 1990·Chemical & Pharmaceutical Bulletin·H ShimadaS Kojima
Jun 1, 1996·Kidney International·M A KnepperS Nielsen

❮ Previous
Next ❯

Citations

Aug 8, 2008·Intensive Care Medicine·Frédérique SchortgenUNKNOWN CRYCO Study Group
Nov 19, 2009·Intensive Care Medicine·Michael JoannidisUNKNOWN Critical Care Nephrology Working Group of the European Society of Intensive Care Medicine
Oct 19, 2010·Journal of Anesthesia·Tomi T NiemiMichiaki Yamakage
Jun 2, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juliane K UngerRolf Rossaint
Sep 3, 2004·Critical Care Medicine·Steven M HollenbergSergio Zanotti-Cavazzoni
Jul 4, 2012·Annals of Intensive Care·Patrick M HonoreHerbert D Spapen
Jun 21, 2006·Critical Care : the Official Journal of the Critical Care Forum·Tanja JohannesCan Ince
Feb 20, 2009·Critical Care : the Official Journal of the Critical Care Forum·James Downar, Stephen E Lapinsky
Mar 20, 2010·Critical Care : the Official Journal of the Critical Care Forum·Nicolas BoussekeyOlivier Leroy
Jun 22, 2005·Clinical Pharmacokinetics·Cornelius Jungheinrich, Thomas A Neff
Jun 17, 2009·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Fu-Chao LiuYuan-Ji Day
Aug 28, 2014·Journal of Veterinary Emergency and Critical Care·Polly A GloverRebecca Kirby
Jun 1, 2006·Journal of the American College of Surgeons·Kathrine Holte, Henrik Kehlet
Jul 25, 2013·The Cochrane Database of Systematic Reviews·Thomas C MutterAllison B Dart
Aug 4, 2018·The Cochrane Database of Systematic Reviews·Sharon R LewisIan Roberts
May 26, 2006·European Journal of Anaesthesiology·I J Davidson
Sep 1, 2007·Current Opinion in Critical Care·Sean M Bagshaw, Rinaldo Bellomo
Jun 14, 2003·European Journal of Anaesthesiology·G Marx
Sep 21, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joachim Boldt
Nov 28, 2002·Current Opinion in Critical Care·Ravindra L MehtaMiet Schetz
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Pablo PerelKatharine Ker
Jun 11, 2009·Anesthesiology·Martin WestphalHugo Van Aken
Jan 14, 2005·The International Journal of Artificial Organs·S M Jakob
Jan 23, 2003·Anesthesia and Analgesia·Joachim Boldt, Hans-Joachim Priebe
Sep 6, 2002·Renal Failure·Marius G DehneGunter Hempelmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.