Hydroxyl radical formation and oxidative DNA damage induced by areca quid in vivo

Journal of Toxicology and Environmental Health. Part a
Chiu-Lan ChenTsung-Yun Liu

Abstract

Chewing areca quid (AQ) has been implicated as a major risk factor for the development of oral squamous-cell carcinoma (OSCC). Recent studies have suggested that AQ-generated reactive oxygen species (ROS) is one of the contributing factors for oral carcinogenesis. However, the AQ used in Taiwan is different from that used in other countries. This study is designed to test whether ROS are generated and the consequent effects in locally prepared AQ in vivo. We measured the hydroxyl radical formation, as represented by the presence of o- and m-tyrosine in saliva from volunteers who chewed AQ containing 20 mg phenylalanine. Their saliva contained significantly higher amounts (p < .05) of o- and m-tyrosine as compared to the controls. In addition, chewing AQ containing Piper betle inflorescence generated higher amounts of m-tyrosine, but not o-tyrosine, in saliva than did chewing AQ containing betel leaf. We further tested the oxidative DNA damaging effect of the reconstituted AQ, as evidenced by the elevation of 8-hydroxy-2'-deoxyguanosine (8-OH-dG) levels, in hamster buccal pouch. Following daily painting for 14 d, the 8-OH-dG level in hamster buccal pouch is significantly elevated (p < .05) in the AQ-treated group versus the cont...Continue Reading

References

Feb 1, 1977·Toxicology·M S BenedettiA L Broillet
Aug 1, 1992·Archives of Biochemistry and Biophysics·Z MaskosW H Koppenol
Sep 5, 1992·Lancet·S J Thomas, R MacLennan
Jul 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoS F Hsieh
May 28, 1992·International Journal of Cancer. Journal International Du Cancer·M A Azuine, S V Bhide
Jan 1, 1991·Free Radical Research Communications·L R KaramM G Simic
Jan 1, 1996·Mutation Research·T Y LiuC W Chi
Nov 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoC C Tsai
Jan 1, 1996·Critical Reviews in Toxicology·J NairH Bartsch
Nov 5, 1997·The Journal of Nursing Administration·T J YinW Y Chang
Sep 25, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T Y LiuC W Chi

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Citations

Mar 29, 2005·Oral Oncology·Sen-Tien TsaiLi-Wha Wu
Aug 3, 2012·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel WillisJudith Zelikoff
Jul 15, 2006·Journal of Toxicology and Environmental Health. Part a·Ping-Ho ChenChung-Ho Chen
Aug 4, 2005·Journal of Toxicology and Environmental Health. Part a·Hui-Ju WuTsung-Yun Liu
Mar 25, 2014·PloS One·Tsu-Nai WangYing-Chin Ko
Jul 26, 2008·Journal of the Chinese Medical Association : JCMA·Peter Mu-Hsin ChangMuh-Hwa Yang
May 22, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shiuan-Shinn LeeYu-Chao Chang
Nov 25, 2014·Oral Diseases·A H KesarwalaJ B Mitchell
Oct 21, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pei-Ling HuangTsung-Yun Liu
May 5, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chia-Chi WangTong-Rong Jan
Mar 27, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C C WangT R Jan
Aug 11, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Ji LiuKuo-Wei Chang
Jan 3, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shiuan-Shinn LeeYu-Chao Chang
Jan 5, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shiuan-Shinn LeeYu-Chao Chang
Jan 21, 2010·Human & Experimental Toxicology·Tasneem Gul KaziSumaira Khan
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Shun-Yao KoTsung-Yun Liu
Jan 30, 2018·BioMed Research International·Ping-Ho ChenKa-Wo Lee
Apr 13, 2005·International Journal of Cancer. Journal International Du Cancer·Shu-Chun LinKuo-Wei Chang
May 27, 2004·British Journal of Cancer·A Z ReznickR M Nagler
Dec 5, 2013·International Journal of Cancer. Journal International Du Cancer·Neela GuhaKurt Straif
Jul 9, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shun-Yao KoTsung-Yun Liu

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