PMID: 9545532Apr 18, 1998Paper

Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide

Biochimica Et Biophysica Acta
A J Nappi, E Vass

Abstract

The highly reactive and cytotoxic hydroxyl radical (OH) was found by electrochemical detection to be produced in reactions involving hydrogen peroxide (H2O2) and the nitric oxide (NO) donor diethylamine- NO complex. Using aromatic hydroxylation of salicylate as a specific indicator of OH, three salicylate hydroxylation products were identified; catechol, 2,3- and 2,5-dihydroxybenzoic acid. Four additional compounds were detected but not identified. The interactions of H2O2 and NO represent a biologically feasible reaction mechanism that can account for OH-induced damage in cellular environments where transition metal ions are unavailable for participation in the superoxide-mediated Fenton reaction. The ability of the NO/H2O2 complex to generate OH independently of iron or other transition metals provides a new focus for studies concerned with the origin of tissue-specific damage caused by oxygen-derived species.

References

Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Jan 1, 1992·Free Radical Research Communications·R SchreckP A Baeuerle
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Nov 13, 1990·European Journal of Biochemistry·B J Bolann, R J Ulvik
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A MoroS Moncada
Nov 17, 1994·Annals of the New York Academy of Sciences·A I Alayash, R E Cashon
Nov 17, 1994·Annals of the New York Academy of Sciences·M B YoudimP Riederer
Oct 1, 1994·British Journal of Pharmacology·S ShimizuK Momose
Aug 15, 1995·European Journal of Biochemistry·G C Brown
Jun 1, 1995·Annals of the Rheumatic Diseases·B Halliwell
Jan 1, 1995·European Journal of Clinical Investigation·T Forslund, T Sundqvist
May 11, 1995·Biochimica Et Biophysica Acta·S PouG M Rosen
Jun 1, 1995·Archives of Biochemistry and Biophysics·A van der VlietC E Cross
Sep 30, 1994·Biochemical and Biophysical Research Communications·X ShiY Mao
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·W A PryorG L Squadrito
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·A I AlayashR E Cashon
Jan 1, 1994·Methods in Enzymology·J S BeckmanJ P Crow
Mar 1, 1994·Free Radical Biology & Medicine·J P CrowJ S Beckman
Jan 1, 1994·Physiological Reviews·B P Yu
Jan 1, 1994·Archives of Biochemistry and Biophysics·R RadiR Telleri
May 1, 1993·Biochemical Society Transactions·J S Beckman, J P Crow
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·N A Simonian, J T Coyle
Jan 1, 1996·Methods in Enzymology·J Kanner
Jul 1, 1996·Chemical Research in Toxicology·H RubboB A Freeman
Jul 1, 1996·Chemical Research in Toxicology·J S Beckman
Dec 1, 1995·Current Opinion in Neurology·J B SchulzM F Beal
Jan 1, 1996·Free Radical Biology & Medicine·S GoldsteinG Czapski

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Citations

May 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A J Nappi, E Ottaviani
Dec 4, 2003·Free Radical Biology & Medicine·Yunpeng DuT S Kern
Jul 24, 2003·Mechanisms of Ageing and Development·Mukarram UddinZhongMao Guo
Jul 30, 2003·Free Radical Biology & Medicine·Hong YangZhongMao Guo
Nov 28, 2012·The British Journal of Nutrition·Ping ZhengDaiwen Chen
Nov 28, 2002·Alimentary Pharmacology & Therapeutics·L Kruidenier, H W Verspaget
Apr 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hong YangZhongMao Guo
Dec 18, 2013·Pharmacology & Therapeutics·Juliana Navarro-YepesRodrigo Franco
Sep 16, 2009·Free Radical Biology & Medicine·Jane A Leopold, Joseph Loscalzo
Jul 11, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ute Koch, Freddy Radtke
Sep 15, 2004·International Journal of Pharmaceutics·V D AwasthiB A Goins
Mar 12, 2013·Cell Metabolism·Judith A Simcox, Donald A McClain
Aug 17, 2000·Nitric Oxide : Biology and Chemistry·A J NappiY Carton
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G Bauer
Sep 14, 2010·Memórias do Instituto Oswaldo Cruz·Eloi S GarciaPatrícia Azambuja
Dec 18, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·E T Saliim, A Abu-Shakra
Nov 5, 2005·World Journal of Gastroenterology : WJG·Joshua-Ka-Shun KoAndrew-Pok-Lap Cheung
Feb 24, 2001·The Journal of Parasitology·E Vass, A J Nappi
May 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Keshari ThakaliStephanie W Watts
Oct 1, 2014·Analytical Methods : Advancing Methods and Applications·Thanakorn PluangklangCharles S Henry
Jan 15, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Deborah KlestadtJaïro Falla

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