PMID: 9165292Jan 1, 1997Paper

Hydroxyl radical is the major causative factor in stress-induced gastric ulceration

Free Radical Biology & Medicine
D DasR K Banerjee

Abstract

The role of the metal-catalyzed production of hydroxyl radicals (OH.) on gastric ulceration caused by restraint-cold stress in rat was studied. Stress causes a 50% increase in the thiobarbituric acid reactive species (TBARS) as a measure of the lipid peroxidation, nearly 70% increase in protein oxidation as measured by its carbonyl content and about 40% decrease in the glutathione content of the fundic stomach, suggesting oxidative damage by stress. Stress also causes a time-dependent increase in the mitochondrial superoxide dismutase activity and a decrease in the peroxidase activity, both of which correlate well with the increase in the severity of ulceration as measured by the ulcer index. Specific OH. scavengers such as benzoate or dimethylsulfoxide (DMSO) and the free radical trap such as alpha-phenyl N-tert-butyl nitrone (PBN) significantly inhibit gastric ulceration suggesting the role of OH. in this oxidative damage. Desferrioxamine (DFO), a nontoxic transition metal ion chelator, protects the mucosa against stress-ulceration dose dependently. Increased level of TBARS and the inactivation of gastric peroxidase are also prevented by DFO or by antioxidants such as glutathione or vitamin E, suggesting the critical role of ...Continue Reading

References

Jan 1, 1976·European Journal of Pharmacology·C H ChoS Dai
Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Jan 1, 1990·Methods in Enzymology·R E Pacifici, K J Davies
Jan 1, 1989·Free Radical Research Communications·B Halliwell
Oct 1, 1989·Gastroenterology·M HirotaM Akagi
May 1, 1986·Archives of Biochemistry and Biophysics·B Halliwell, J M Gutteridge
May 15, 1986·Archives of Biochemistry and Biophysics·I Fridovich
Apr 1, 1987·British Medical Bulletin·D R BlakeJ Lunec
Mar 1, 1988·Stroke; a Journal of Cerebral Circulation·E D Hall, P A Yonkers
Jul 1, 1988·Digestive Diseases and Sciences·I Szelenyi, K Brune
Apr 1, 1987·Gastroenterology·S M SmithP R Kvietys
Dec 1, 1987·Digestive Diseases and Sciences·G PihanS Szabo
Feb 1, 1986·Gastroenterology·M A PerryD N Granger
Nov 1, 1980·The Biochemical Journal·J F Turrens, A Boveris
Jan 1, 1995·The Biochemical Journal·D DasR K Banerjee
Apr 1, 1994·Free Radical Biology & Medicine·S ChakrabortyI B Chatterjee
Aug 25, 1993·Molecular and Cellular Biochemistry·D Das, R K Banerjee
May 1, 1993·Biochemical Society Transactions·B E Hedlund, P E Hallaway
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M ChevionN Kitrossky
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·B D SanterM F Wehner

❮ Previous
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Citations

Dec 20, 2007·Archives of Pharmacal Research·G Ozbakis DengizY Bayir
Feb 24, 2001·Journal of Physiology and Biochemistry·O Martínez-AugustínF Sánchez de Medina
Jun 8, 2010·Journal of Natural Medicines·Masako HoriuchiYoshiyuki Seyama
May 15, 2012·Journal of Physiology and Biochemistry·Masoud AlirezaeiArash Kheradmand
Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jae-Young JeSe-Kwon Kim
Dec 25, 2003·Journal of Pediatric Surgery·Savaş DemirbilekNecla Gürbüz
Aug 10, 2002·Journal of Ethnopharmacology·K SairamR K K Goel
Jun 3, 2000·Gastroenterology Clinics of North America·U Beejay, M M Wolfe
Apr 10, 2002·Pathology International·Kenji NoguchiHironobu Sasano
Jul 16, 2010·Journal of Asian Natural Products Research·Shailja SoodPritam Dev Sharma
Mar 10, 2001·Antioxidants & Redox Signaling·Y Kotake
Dec 5, 2008·Journal of Medicinal Food·Beong Ou LimPyo-Jam Park
Jul 30, 2011·Evidence-based Complementary and Alternative Medicine : ECAM· VismayaSindhu Kanya C Thirumakudalu
Dec 22, 2011·Chemistry Central Journal·Bharat Bhusan Subudhi, Shakti Prasanna Sahoo
Sep 4, 2009·Journal of Hematology & Oncology·Subhash PadhyeFazlul H Sarkar
Nov 24, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshiya Asano
Sep 19, 2009·World Journal of Gastroenterology : WJG·Stephanie Schulz-GeskeNina Grosser
Mar 31, 2011·World Journal of Gastroenterology : WJG·Noha N NassarDalaal M Abdallah
Mar 26, 2010·Pakistan Journal of Biological Sciences : PJBS·Raden Arthur Ario LelonoKazutaka Itoh
Feb 7, 2014·Pakistan Journal of Biological Sciences : PJBS·Raden Arthur Ario Lelono, Sanro Tachibana
Nov 1, 2008·Indian Journal of Pharmacology·Manish A Rachchh, Sunita M Jain
Jul 21, 2011·Journal of Pharmacology & Pharmacotherapeutics·Ashok A Muchandi, V M Chandrashekhar
Dec 5, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jing-Yang WongVikineswary Sabaratnam
May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Gehan Moustafa Badr, Jawaher Abdulaziz Al-Mulhim
Apr 2, 2014·TheScientificWorldJournal·Konstantin V KudryavtsevNikolay S Zefirov
Jun 3, 2015·Pakistan Journal of Biological Sciences : PJBS·Agus Sukito, Sanro Tachibana
Jul 2, 2014·Journal of Natural Medicines·Sirshendu ChatterjeeSandip K Bandyopadhyay
Sep 18, 2012·Journal of Natural Medicines·Gedson Rodrigues de Morais LimaLeônia Maria Batista
Nov 14, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ju-Young KoYou-Jin Jeon
Oct 16, 2015·Journal of Medicinal Food·Hong-Mei ZhengDon Haeng Lee
Jan 20, 2010·Journal of Ethnopharmacology·M Bavani EswaranCh V Rao
May 19, 2009·Gastroenterology Clinics of North America·Tauseef Ali, Richard F Harty
Jan 14, 2009·Phytotherapy Research : PTR·Pallab MaityUday Bandyopadhyay

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