Hydroxyl radical scavenging mechanism of human erythrocytes by quercetin-germanium (IV) complex

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Sheng-Pu LiPei-Hui Yang

Abstract

Quercetin is a popular flavonoid in plant foods, herbs, and dietary supplement. Germanium, a kind of trace elements, can enhance the body immunity. This study investigated the hydroxyl-radical-scavenging mechanism of the quercertin-germanium (IV) (Qu-Ge) complex to human erythrocytes, especially the effects on ultrastructure and mechanical properties of cell membrane, plasma membrane potential and intracellular free Ca(2+) concentration. Results showed that QuGe(2), a kind of the Qu-Ge complex, could reduce the oxidative damage of erythrocytes, change the cell-surface morphology, and partly recover the disruption of plasma membrane potential and intracellular free Ca(2+) level. Atomic force microscopy (AFM) was used to characterize the changes of the cell morphology, cell-membrane ultrastructure and biophysical properties at nanoscalar level. QuGe(2) has triggered the antioxidative factor to inhibit cellular damage. These results can improve the understanding of hydroxyl-radical-scavenging mechanism of human erythrocytes induced by the Qu-Ge complex, which can be potentially developed as a new antioxidant for treatment of oxidative damage.

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Citations

May 3, 2015·IEEE Transactions on Nanobioscience·Rashmi MukherjeeChandan Chakraborty
Jul 26, 2016·Intensive Care Medicine Experimental·Shuai MaFeng Ding
Dec 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Kanchana Kengkoom, Sumate Ampawong

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