Hydroxyl radicals are involved in the oxidation of isolated and cellular DNA bases by 5-aminolevulinic acid

FEBS Letters
T DoukiP Di Mascio

Abstract

5-Aminolevulinic acid (ALA) is a heme precursor, pathological accumulation of which is associated with liver cancer. We show that the reactive oxygen species produced upon ALA metal-catalyzed oxidation promote the formation of several radical-induced base degradation products in isolated DNA. The distribution of modified bases is similar to that obtained upon gamma irradiation. This observation strongly suggests the involvement of hydroxyl radicals in the ALA-mediated DNA damage. Increased levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 5-hydroxy-2'-deoxycytidine in organ DNA of rats chronically treated with ALA were observed. This is strongly suggestive of the implication of hydroxyl radicals in the ALA-induced degradation of cellular DNA.

References

Jan 15, 1975·Biochemical Pharmacology·F B McGillionA Goldberg
Jul 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·J C Kennedy, R H Pottier
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J R WagnerB N Ames
Oct 1, 1990·The American Journal of Medicine·J G GublerU A Meyer
Jan 1, 1990·Methods in Enzymology·M Dizdaroglu, E Gajewski
Jan 1, 1990·Free Radical Biology & Medicine·R A FloydJ E Schneider
Jan 1, 1989·Free Radical Biology & Medicine·H C Sutton, C C Winterbourn
Jan 1, 1986·Free Radical Research Communications·R A FloydR C Rickard
Feb 1, 1971·Scientific American·J J Chisolm
Jan 1, 1984·Acta Medica Scandinavica·F Lithner, L Wetterberg
Oct 1, 1996·Chemical Research in Toxicology·T DoukiJ Cadet
Feb 1, 1997·Photochemistry and Photobiology·Q PengJ M Nesland
Jun 1, 1997·Journal of Radiation Research·N Murata-KamiyaH Kasai
Mar 25, 1998·Chemical Research in Toxicology·T DoukiP Di Mascio

❮ Previous
Next ❯

Citations

Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·M KarbownikR J Reiter
Jan 6, 2000·Archives of Biochemistry and Biophysics·P Di MascioJ Cadet
Jan 13, 2006·Cancer Chemotherapy and Pharmacology·E S M ChuJ Y Chen
Mar 5, 1999·Mutation Research·J CadetS Sauvaigo
Apr 15, 2004·The Science of the Total Environment·V MuzykaT Veidebaum
Sep 27, 2002·Toxicology·Ping-Chi Hsu, Yueliang Leon Guo
Nov 21, 2000·Free Radical Biology & Medicine·H Gurer, N Ercal
Dec 19, 2000·Free Radical Biology & Medicine·M E RochaE J Bechara
May 12, 2009·BMC Cancer·Thissiane L GonçalvesJoão Batista T Rocha
May 7, 2011·Veterinary Medicine International·R C PatraD Swarup
Dec 23, 2015·International Journal of Molecular Sciences·Arif Tasleem JanQazi Mohd Rizwanul Haq
Aug 23, 2011·Pathology, Research and Practice·Carlos A PrauchnerJoão B T da Rocha
Jul 5, 2012·Journal of Applied Toxicology : JAT·Laura Musacchio VargasFrancielli Weber Santos
Apr 7, 2011·Free Radical Biology & Medicine·Chrislaine O SoaresEtelvino J H Bechara
Dec 26, 2006·Chemico-biological Interactions·Cristiane LucheseFrancielli W Santos
Jan 6, 2004·Free Radical Research·Fernando DutraEtelvino J H Bechara
Feb 13, 2018·Critical Reviews in Toxicology·Iara Dantas de SouzaRodrigo Juliani Siqueira Dalmolin
Jan 29, 2008·Radiation Research·Bulent AydoganDavid T Marshall
Mar 27, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Adriane C da SilvaMaria R C Schetinger
Aug 19, 2009·Neurotoxicology and Teratology·Edward F KriegUNKNOWN CDC/NCI NHANES III Genomics Working Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.