Hydroxylated PCB induces Ca2+ oscillations and alterations of membrane potential in cultured cortical cells

Journal of Applied Toxicology : JAT
Marina LondoñoNoriyuki Koibuchi

Abstract

Polychlorinated biphenyls (PCBs) are known as environmental pollutants that may cause adverse health effects. Although some congeners have been shown to affect brain development or function, the molecular mechanisms mediating their toxicity are not yet fully understood. Since signal transduction via intracellular Ca(2+) is crucial for neuronal development and plasticity, we investigated the effect of PCBs on Ca(2+) homeostasis and membrane potential in cultured mouse cortical cells. Acute exposure to hydroxylated PCB 106 [4(OH)-2',3,3',4',5'-pentachlorobiphenyl, OH-PCB 106, 0.1 microM] caused recurring Ca(2+) oscillations that were classified into three prototypes. Although extracellular Ca(2+) deprivation significantly reduced the oscillations, 54% of the cells still showed different patterns of oscillations or gradual increase in the intracellular Ca(2+) concentration, indicating possible involvement of multiple Ca(2+) channels in a cell-specific manner. Such a possibility was further confirmed by differential responses to several channel/receptor blockers, including nifedipine, ryanodine, xestospongine and tetrodotoxin. Although all chemicals had partial inhibition action in different subsets of neurons, nifedipine blocked t...Continue Reading

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Citations

Jan 30, 2015·Critical Reviews in Toxicology·Fabian A GrimmLarry W Robertson
May 22, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shintaro MiseHideyuki Inui
Oct 5, 2016·Environmental Science and Pollution Research International·Jianteng SunLizhong Zhu
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Jun 9, 2014·Analytical and Bioanalytical Chemistry·Natalia QuineteThomas Kraus
Nov 1, 2014·Expert Review of Endocrinology & Metabolism·Kingsley Ibhazehiebo, Noriyuki Koibuchi
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Feb 9, 2016·Environmental Science & Technology Letters·Andrew M AwadKeri C Hornbuckle

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