Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus)

Environmental Research
Lisa GustavsonBjorn Munro Jenssen

Abstract

As a top predator in the Arctic food chain, polar bears (Ursus maritimus) are exposed to high levels of persistent organic pollutants (POPs). Because several of these compounds have been reported to alter endocrine pathways, such as the steroidogenesis, potential disruption of the sex steroid synthesis by POPs may cause implications for reproduction by interfering with ovulation, implantation and fertility. Blood samples were collected from 15 female polar bears in Svalbard (Norway) in April 2008. The concentrations of nine circulating steroid hormones; dehydroepiandrosterone (DHEA), androstenedione (AN), testosterone (TS), dihydrotestosterone (DHT), estrone (E1), 17α-estradiol (αE2), 17β-estradiol (βE2), pregnenolone (PRE) and progesterone (PRO) were determined. The aim of the study was to investigate associations among circulating levels of specific POP compounds and POP-metabolites (hydroxylated PCBs [OH-PCBs] and hydroxylated PBDEs [OH-PBDEs]), steroid hormones, biological and capture variables in female polar bears. Inverse correlations were found between circulating levels of PRE and AN, and circulating levels of OH-PCBs. There were no significant relationships between the steroid concentrations and other analyzed POPs or...Continue Reading

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Citations

Oct 10, 2014·The Science of the Total Environment·Kathrine Eggers PedersenBjørn Munro Jenssen
Oct 23, 2016·Environment International·Kathrine Eggers PedersenBjarne Styrishave
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Feb 14, 2021·Environmental Pollution·Yi-Ping ChenKai-Bo Wang
Sep 18, 2017·Environmental Research·Katrin S HoydalBjørn M Jenssen

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