Hydroxylation and glucuronidation of various xenobiotics by hepatic microsomes from the fetal lamb, pregnant ewe and human fetus

Developmental Pharmacology and Therapeutics
B H DvorchikW A Tweed

Abstract

The ability of microsomes isolated from liver of pregnant ewes and their fetuses at near term to catalyze the biotransformation of benzo[a]pyrene, hexobarbital, meperidine, methadone and morphine was investigated. Cytochromes P-450 and b5, NADPH and NADH cytochrome c reductase, methadone and meperidine N-demethylase and morphine glucuronyltransferase activities were detected in microsomes from both maternal and fetal livers. Fetal hepatic microsomes however, lacked the ability to catalyze the hydroxylation of hexobarbital and benzo[a]pyrene.

Citations

Dec 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·M KaddouriP Galtier
Sep 1, 1994·Journal of Clinical Pharmacology·D G May
Jan 31, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marianne GarlandRaymond I Stark
Jan 13, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tanguy CorbelNicole Picard-Hagen
Sep 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·G LarrieuP Galtier
Jul 17, 1998·Pediatric Research·M GarlandR I Stark
Feb 9, 2000·Pharmacology & Therapeutics·J A RingD J Morgan
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·G Larrieu, P Galtier

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