Hydroxylation of dehydroepiandrosterone in human scalp hair follicles

The British Journal of Dermatology
A J VermorkenH Bloemendal

Abstract

The dehydroepiandrosterone hydroxylating enzyme system in the hair follicle has been characterized. It is found in the particulate fraction of the follicle, and is inhibited by carbon monoxide and the cytochrome P450 inhibitor metyrapone, and appears to be dependent upon NADPH. In these major characteristics the hair follicle enzyme is very similar to the liver monooxygenase system.

References

Jan 1, 1982·Archives of Dermatological Research·S Itami, S Takayasu
Oct 1, 1979·Toxicology·A J VermorkenH Bloemendal
Jan 17, 1997·Forensic Science International : Synergy·L PötschM R Moeller
Aug 1, 1981·Psychological Medicine·I C McManus
Jan 1, 1990·Drug Metabolism Reviews·J Kao, M P Carver
Jun 1, 1980·The British Journal of Dermatology·A J VermorkenH M Roelofs

Citations

Nov 1, 1977·The British Journal of Dermatology·C H de BruynP Hösli
Feb 1, 1978·The British Journal of Dermatology·A J VermorkenT L Oei
Jul 1, 1979·The British Journal of Dermatology·C H de BruynS J Geerts
Jun 29, 1976·Human Genetics·T GrimmH H Ropers
Oct 1, 1971·Steroids·A G Fazekas, A Lanthier
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·A G Fazekas, T Sandor

Related Concepts

Entire Hair Follicle
SU 4885
Downy Hair
Metyrapone
Cytochrome P450
Scalp Structure
Carbon Monoxide
Androstenediols
Ovarian Follicle
Cytochrome P450 Activity

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