PMID: 5910019Apr 1, 1966

Hydroxylation of proline and the intracellular accumulation of a polypeptide precursor of collagen

Science
K JUVAJ W Lash

Abstract

Autoradiographs of embryonic cartilage indicated that labeled protein accumnulated intracellularly when the tissue was incubated with tritiated proline, and when the hydroxylation of proline was inhibited by anaerobic conditions or by a chelator for ferrous iron. The labeled protein apparently corresponds to protocollagen. the polypeptide precursor of collagen which serves as a substrate for the enzymatic synthesis of hydroxyproline.

Citations

Mar 1, 1979·The American Journal of Anatomy·M A Kerley, E J Kollar
Jul 1, 1976·The Journal of Experimental Zoology·D B Galbraith, E J Kollar
May 1, 1973·Biochemical and Biophysical Research Communications·S A JimenezJ Rosenbloom
Aug 1, 1967·Comparative Biochemistry and Physiology·H E Firschein
Oct 1, 1968·Developmental Biology·H GreenD D Brown
Mar 1, 1984·Collagen and Related Research·V DamianoJ Rosenbloom
Feb 3, 1972·The New England Journal of Medicine·M E Grant, D J Prockop
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·K Kivirikko, D J Prockop
Jul 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·R S BhatnagarD J Prockop
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·I Bekhor, L A Bavetta
Apr 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·K M Towe
May 1, 1992·The Journal of Cell Biology·A NakaiKazuhiro Nagata
Aug 1, 1968·The Journal of Cell Biology·A L Horwitz, A Dorfman
Apr 1, 1972·Annals of Surgery·J NiinikoskiT K Hunt
Nov 1, 1967·Biological Reviews of the Cambridge Philosophical Society·P J Peterson
Sep 30, 1975·Annals of the New York Academy of Sciences·C I Levene, C J Bates
Mar 1, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kshipra SinghKeith T Wilson
Jan 29, 2014·Plastic and Reconstructive Surgery·Jeffrey E Janis, Bridget Harrison
Jun 3, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Paola G RodriguezElisabeth K Shim
Oct 1, 1974·Journal of Cellular Physiology·K NoseH Katsuta
Apr 15, 1972·Biochimica Et Biophysica Acta·C J BatesC I Levene
Aug 1, 1978·Teratology·A Oohira, H Nogami
Jan 1, 1981·Connective Tissue Research·V DamianoJ Rosenbloom
Sep 1, 1980·Archives of Biochemistry and Biophysics·J ScheinJ Rosenbloom
Mar 1, 1967·Archives of Biochemistry and Biophysics·H E Firschein
Sep 9, 1974·Biochemical and Biophysical Research Communications·J Uitto, D J Prockop
Oct 1, 1979·Archives of Biochemistry and Biophysics·K TakedaK Konno
Jan 1, 1969·Archives of Biochemistry and Biophysics·T J GribbleS Udenfriend
Mar 1, 1968·Biochemical Pharmacology·B Rokosová-Cmuchalová, J P Bentley
Aug 1, 1974·Archives of Biochemistry and Biophysics·S A Jimenez, J Rosenbloom
Oct 1, 1973·Archives of Biochemistry and Biophysics·J RosenbloomS A Jimenez
Nov 1, 1992·The American Journal of Emergency Medicine·L D Weiss, K W Van Meter
Jan 1, 1994·Clinics in Dermatology·R N Roth, L D Weiss
Dec 4, 1972·Biochemical and Biophysical Research Communications·B Peterkofsky
Oct 1, 1981·Scandinavian Journal of Dental Research·K Helgeland
Jun 15, 1981·International Journal of Cancer. Journal International Du Cancer·K AlitaloA Vaheri
Jan 1, 1983·Annals of the New York Academy of Sciences·J B GelderdD W Welch
Apr 1, 1997·International Journal of Oral and Maxillofacial Surgery·P C TompachJ L Stoll
Feb 1, 1977·Archives of Biochemistry and Biophysics·D T VisticaW R Ellison
Dec 1, 1971·Archives of Biochemistry and Biophysics·R L Margolis, L N Lukens
Nov 17, 1975·Biochemical and Biophysical Research Communications·S A Jimenez, R Yankowski
Jan 1, 1971·Acta Rheumatologica Scandinavica·T Böhmer
Aug 25, 2016·Plastic and Reconstructive Surgery·Jeffrey E Janis, Bridget Harrison
Jul 21, 1970·Biochemistry·B N Bachra, A J Van Der Eb
Nov 1, 1971·Biochemistry·D Sadava, M J Chrispeels
Jun 1, 1974·The British Journal of Surgery·T T Irvin, T K Hunt
Jul 1, 1975·Journal of Dental Research·S HetemJ A Yaeger
Aug 30, 1996·The Journal of Biological Chemistry·K BeckH P Bächinger
Aug 15, 1998·The Journal of Biological Chemistry·C IllidgeA Shuttleworth
Aug 15, 2001·American Journal of Physiology. Renal Physiology·P A NonyR G Schnellmann
Feb 1, 1975·CRC Critical Reviews in Biochemistry·A Veis, A G Brownell
Mar 20, 1978·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·U Langness, E Löwensprung
May 18, 2017·Stem Cells International·Cristina D'AnielloGabriella Minchiotti

Related Concepts

Autoradiography
Carbon Isotopes
Cartilage
Metal Antagonists
Chick Embryo
Zyderm
Hydroxyproline
Polypeptides
Proline
Sulfur Isotopes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
L N Lukens
Proceedings of the National Academy of Sciences of the United States of America
R S BhatnagarD J Prockop
Proceedings of the National Academy of Sciences of the United States of America
D J Prockop, K JUVA
© 2021 Meta ULC. All rights reserved