PMID: 11325228Apr 28, 2001Paper

Hydroxylations and methylations of quercetin, fisetin, and catechin by Streptomyces griseus

Journal of Natural Products
Mohammed HosnyJ P Rosazza

Abstract

Preparative-scale biotransformation of quercetin (1), fisetin (7), and (+)-catechin (12) with Streptomyces griseus (ATCC 13273) resulted in the isolation and characterization of nine known hydroxylated and/or methylated (2--6, 8, 9, 11, 13a) metabolites and two previously unknown (10 and 14) metabolites. S.griseus catalyzed aromatic hydroxylations of rings A and B of quercetin and fisetin. Mono- and dimethoxy ring-B metabolites were obtained with all three substrates. Methylation appeared to occur only when catechol functional groups were present. Metabolite structures were established by FABMS, EIMS, and 1D and 2D NMR analysis.

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Citations

Nov 19, 2009·Applied Microbiology and Biotechnology·Nai-Dong ChenBo-Yang Yu
Oct 31, 2003·Bioresource Technology·Rex Montgomery
Jun 2, 2012·TheScientificWorldJournal·Edyta Kostrzewa-Susłow, Tomasz Janeczko
May 18, 2005·Phytochemistry·Galal T Maatooq, John P N Rosazza
Jan 26, 2006·Bioorganic & Medicinal Chemistry Letters·Ji-Hua LiuYi-Jun Chen
Aug 2, 2005·Biochimica Et Biophysica Acta·Youngdae YoonYoongho Lim
Feb 11, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta BerniniMaria Cristina Ginnasi
Apr 28, 2020·Critical Reviews in Biotechnology·Zeinab T Abdel ShakourMohamed A Farag
Apr 29, 2006·Journal of Natural Products·Toshihiro AkihisaYumiko Kimura
Feb 2, 2006·Journal of Agricultural and Food Chemistry·Bong-Gyu KimJoong-Hoon Ahn
Jul 13, 2021·International Journal of Microbiology·Lasata ShresthaBishnu Prasad Pandey
Sep 6, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M SilberbergC Morand
Jun 5, 2018·Journal of Agricultural and Food Chemistry·Miao-Chan HuangTung-Hu Tsai
Apr 24, 2004·Journal of Natural Products·M Sanchez-Gonzalez, J P N Rosazza
Sep 19, 2002·Journal of Agricultural and Food Chemistry·Mohammed Hosny, John P N Rosazza
Jan 19, 2006·Journal of Agricultural and Food Chemistry·Subhashinee S K WijeratneFereidoon Shahidi
Mar 28, 2006·Journal of Natural Products·Shuvendu Das, John P N Rosazza

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