Hydroxypropyl-β-cyclodextrin-graphene oxide conjugates: Carriers for anti-cancer drugs

Materials Science & Engineering. C, Materials for Biological Applications
Jingting TanNinglin Zhou

Abstract

A novel drug carrier based on hydroxypropyl-β-cyclodextrin (HP-β-CD) modified carboxylated graphene oxide (GO-COOH) was designed to incorporate anti-cancer drug paclitaxel (PTX). The formulated nanomedicines were characterized by Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Results showed that PTX can be incorporated into GO-COO-HP-β-CD nanospheres successfully, with an average diameter of about 100 nm. The solubility and stability of PTX-loaded GO-COO-HP-β-CD nanospheres in aqueous media were greatly enhanced compared with the untreated PTX. The results of hemolysis test demonstrated that the drug-loaded nanospheres were qualified with good blood compatibility for intravenous use. In vitro anti-tumor activity was measured and results demonstrated that the incorporation of PTX into the newly developed GO-COO-HP-β-CD carrier could confer significantly improved cytotoxicity to the nanosystem against tumor cells than single application of PTX. GO-COO-HP-β-CD nanospheres may represent a promising formulation platform for a broad range of therapeutic agent, especially those with poor solubility.

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Citations

Dec 10, 2016·Journal of Biomaterials Science. Polymer Edition·Junmei WangSufang Li
Apr 13, 2017·Biomaterials Science·Shine AugustineBansi D Malhotra
Sep 12, 2018·Beilstein Journal of Organic Chemistry·Artur KasprzakMagdalena Poplawska
Jul 31, 2020·Expert Opinion on Drug Delivery·Cuiping JiangQiang Liu
Aug 19, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Anna TrusekLudomira Granicka
Aug 10, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jing ZhangJie Feng

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