PMID: 8602110Jan 1, 1996Paper

Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and stability of anandamide

Life Sciences
P JarhoT Järvinen

Abstract

Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the present study, it was found that AEA forms inclusion complexes with cyclodextrins (CDs), resulting in greater aqueous solubility and stability of AEA as AEA/CD complex. Aqueous solubility increased 1 000 to 30 000-fold, depending on the type of CD (10% solution) used. The half-life of AEA in aqueous hydroxypropyl-beta-cyclodextrin solution (10%) at 50 degree C was 2.9 years. These results suggest that CD-technology will be a very useful method to overcome the solubility and stability problems of AEA.

References

May 1, 1994·Medicinal Research Reviews·J Szejtli
Jun 10, 1994·Journal of Medicinal Chemistry·V AbadjiA Makriyannis
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C C FelderW A Devane
Oct 1, 1993·Journal of Medicinal Chemistry·L HanusR Mechoulam

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Citations

May 6, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Juha JuntunenTomi Järvinen
Sep 6, 2000·Journal of Clinical Pharmacy and Therapeutics·H S LinP C Ho
Jan 25, 2005·Bioscience, Biotechnology, and Biochemistry·Minoru IshikawaTakeshi Furuta
Oct 12, 2004·Biochemical and Biophysical Research Communications·Burkhard HinzKay Brune
Mar 24, 2011·Journal of Microencapsulation·M R AberturasJ Molpeceres
Aug 18, 2005·The Journal of Pharmacy and Pharmacology·Juha JuntunenRiku Niemi
Sep 17, 2010·Journal of Neurophysiology·Maciej Dominik PietrZvi Vogel
Aug 17, 2020·Current Opinion in Allergy and Clinical Immunology·Leonard Bielory, Nikko Rowe A Tabliago
Feb 19, 2002·Chemical Reviews·Kaneto UekamaTetsumi Irie

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