PMID: 18203894Jan 22, 2008Paper

Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women

The Journal of Nutrition
K C MakiMatthew S Reeves

Abstract

Hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) are modified cellulose dietary fibers that generate viscous solutions in the gastrointestinal (GI) tract. This study assessed the effects of high viscosity (HV) HPMC, ultra-HV (UHV) HPMC, and medium viscosity MC on postprandial glucose and insulin responses in overweight and obese men and women (n = 50). After overnight fasts, subjects consumed 5 breakfast meals containing 75 g carbohydrate, each of which contained 1 of the following: 1 g HV-HPMC, 2 g HV-HPMC, 2 g UHV-HPMC, 4 g medium-viscosity MC or control (2 g cellulose). Test sequence was randomized and double-blind, except the MC test, which was last and single-blind (46 subjects completed all 5 tests). Glucose and insulin responses were determined pre-meal and for 120 min postprandially. Median (interquartile limits) peak glucose concentration was lower (P = 0.001) after the meal containing 2.0 g UHV-HPMC (7.1, 6.3-8.2 mmol/L) compared with the control meal (7.7, 6.6-8.7 mmol/L). The control did not differ from the other conditions for peak glucose or for any of the HPMC/MC conditions for glucose incremental areas under the curves (IAUC). Peak insulin was reduced (P < 0.05) for all HPMC/MC conditions compared wi...Continue Reading

References

May 27, 1978·British Medical Journal·D J JenkinsK G Alberti
Aug 1, 1992·Diabetes Research and Clinical Practice·C Reppas, J B Dressman
Mar 1, 1992·Diabetes Care·R A DeFronzoE Ferrannini
Aug 1, 1991·Journal of the American College of Nutrition·T M WoleverD J Jenkins
Mar 1, 1984·Clinical Science·N A BlackburnN W Read
Apr 1, 1994·The American Journal of Clinical Nutrition·C J LeclèreJ P Galmiche
Oct 1, 1993·Diabetes Research and Clinical Practice·C ReppasJ B Dressman
Jan 30, 1999·The American Journal of Clinical Nutrition·L BrownF M Sacks
May 26, 1999·Regulatory Toxicology and Pharmacology : RTP·B BuemannA Astrup
Jun 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C ReppasJ B Dressman
Nov 24, 1999·The American Journal of Cardiology·K C MakiB P Daggy
Jun 28, 2002·Lancet·Jean-Louis ChiassonUNKNOWN STOP-NIDDM Trail Research Group
Nov 1, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Bianchi, L Capurso
Feb 5, 2003·The American Journal of Medicine·David J A JenkinsVladimir Vuksan
Jul 24, 2003·JAMA : the Journal of the American Medical Association·Jean-Louis ChiassonUNKNOWN STOP-NIDDM Trial Research Group
Apr 10, 2004·Stroke; a Journal of Cerebral Circulation·Markolf HanefeldTheodora Temelkova-Kurktschiev
Jul 28, 2004·The American Journal of Clinical Nutrition·Matthias B SchulzeFrank B Hu
Dec 30, 2006·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee

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Citations

Nov 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura M CoxMartin J Blaser
Jul 6, 2014·The Journal of Nutrition·David A BrockmanDaniel D Gallaher
Aug 3, 2012·Journal of the American College of Nutrition·Shireen DowDavid L Gee
Mar 21, 2019·The Journal of Infectious Diseases·Sangun LeeSaul Tzipori
May 1, 2009·Journal of Clinical Lipidology·Kevin C MakiTia M Rains

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