Hydroxysafflor Yellow A Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice

Phytotherapy Research : PTR
Ming JinLi Tan

Abstract

Hydroxysafflor yellow A (HSYA) is an active component of Carthamus tinctorius L., and we want to investigate whether HSYA attenuates pulmonary fibrosis induced by bleomycin (BLM) in mice. The mice received a BLM via oropharyngeal aspiration, and HSYA was intraperitoneally injected. Arterial blood gas analysis was performed. Morphological changes and hydroxyproline content were measured. mRNA expression of transforming growth factor-β1 (TGF-β1), connective tissue growth factor, α-smooth muscle actin (α-SMA), and collagen I was measured by real-time polymerase chain reaction. α-SMA-positive cells in lung tissues were detected by immunohistochemical staining. A549 cell was cultured, and morphological changes were observed after TGF-β1 and HSYA treatment. mRNA expression was detected by real-time polymerase chain reaction. Phosphorylation of Smad3 was evaluated by western blotting. HSYA decreased the lung consolidation area and collagen deposition in mice with pulmonary fibrosis. The blood gas changes due to BLM were attenuated by HSYA. HSYA also alleviated the BLM-induced increase of TGF-β1, connective tissue growth factor, α-SMA, and collagen I mRNA levels. HSYA treatment inhibited the increase of α-SMA expression, Smad3 phosphor...Continue Reading

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Citations

Jul 28, 2016·The Journal of Pharmacy and Pharmacology·Ruiyan PanMing Jin
Aug 9, 2017·Inflammation·Yong ZhouCha-Xiang Guan
Sep 18, 2020·The Journal of International Medical Research·Hai LiXiangdong Jian
Oct 27, 2017·Environmental Science and Pollution Research International·Hong YangBing Shi
Oct 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Hui AoCheng Peng
Sep 4, 2020·Phytotherapy Research : PTR·Sai Manohar ThotaVenketesh Sivaramakrishnan
Feb 7, 2021·BioFactors·Seyede Atefe HosseiniAmirhossein Sahebkar
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sarasadat HosseiniGholamreza Karimi

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