Hydroxytyrosol Plays Antiatherosclerotic Effects through Regulating Lipid Metabolism via Inhibiting the p38 Signal Pathway.

BioMed Research International
Xinxin ZhangXiaomei Guo

Abstract

Hydroxytyrosol (HT) processes multiaspect pharmacological properties such as antithrombosis and antidiabetes. The aim of this study was to explore the antistherosclerotic roles and relevant mechanisms of HT. Male apoE-/- mice were randomly divided into 2 groups: the control group and the HT group (10 mg/kg/day orally). After 16 weeks, blood tissue, heart tissue, and liver tissue were obtained to detect the atherosclerotic lesions, histological analysis, lipid parameters, and inflammation. And the underlying molecular mechanisms of HT were also studied in vivo and in vitro. HT administration significantly reduced the extent of atherosclerotic lesions in the aorta of apoE-/- mice. We found that HT markedly lowered the levels of serum TG, TC, and LDL-C approximately by 17.4% (p = 0.004), 15.2% (p = 0.003), and 17.9% (p = 0.009), respectively, as well as hepatic TG and TC by 15.0% (p < 0.001) and 12.3% (p = 0.003), respectively, while inducing a 26.9% (p = 0.033) increase in serum HDL-C. Besides, HT improved hepatic steatosis and lipid deposition. Then, we discovered that HT could regulate the signal flow of AMPK/SREBP2 and increase the expression of ABCA1, apoAI, and SRBI. In addition, HT reduced the levels of serum CRP, TNF-α, IL...Continue Reading

References

Feb 18, 2009·Circulation·Fiona C McGillicuddyMuredach P Reilly
Sep 18, 2010·Mediators of Inflammation·Zhaoxia Wang, Tomohiro Nakayama
Oct 12, 2010·International Journal of Epidemiology·Shanthi MendisUNKNOWN Writing group on behalf of the participating experts of the WHO consultation for revision of WHO definition of myocardial in
Jan 19, 2012·Nutrients·Fernando WarletaJosé J Gaforio
Sep 27, 2014·Current Opinion in Cell Biology·D Grahame Hardie
Oct 17, 2014·Immunological Reviews·Sophie ColinBart Staels
Oct 11, 2016·Current Drug Targets·Silvia TejadaAntoni Sureda
Jan 9, 2017·The Canadian Journal of Cardiology·Hong Y ChoiJacques Genest
Mar 25, 2017·Nutrients·Julien PeyrolMarie Josèphe Amiot
May 22, 2017·Journal of the American College of Cardiology·Gregory A RothChristopher Murray
Aug 30, 2017·The New England Journal of Medicine·UNKNOWN HPS3/TIMI55–REVEAL Collaborative GroupMartin J Landray
Nov 11, 2017·Annual Review of Physiology·Wen-Jun ShenFredric B Kraemer
Dec 27, 2018·Current Opinion in Lipidology·Amy C BurkeMurray W Huff
Dec 28, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Soo LimJan Borén
Feb 6, 2019·Trends in Endocrinology and Metabolism : TEM·Chiara VantaggiatoMarco Pozzi
Feb 17, 2019·Atherosclerosis·Philip Barter, Jacques Genest
Mar 6, 2019·Phytotherapy Research : PTR·Cheng LiYonggang Wang
Mar 14, 2019·The New England Journal of Medicine·Kausik K RayUNKNOWN CLEAR Harmony Trial
Mar 30, 2019·Life Sciences·Saleh Rahmati-AhmadabadHossein Shirvani
Jul 12, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuanyuan LiYanqiao Zhang

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